Evidence map›Paper›PMID 28645223›Full record

ArticleJournal of aging and health2018

Decline in Literacy and Incident AD Dementia Among Community-Dwelling Older Persons.

Lei Yu, Robert S Wilson, S Duke Han, Sue Leurgans, David A Bennett, Patricia A Boyle

Abstract read
In one paragraph

Article in Journal of aging and health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Health and Financial Literacy and the Acquisition of COVID-19 Knowledge in Older Adults.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025
    Article
  3. Article
  4. Change in Decision-Making Analysis and Preferences in Old Age.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023
    Article
  5. Well-Being and Aging-Related Decline in Financial and Health Literacy in Advanced Age.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Adverse Impacts of Declining Financial and Health Literacy in Old Age.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
    Article
  10. Aging and Functional Health Literacy: A Population-based Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Associations of literacy with diabetes indicators in older adults.Journal of epidemiology and community health · 2019
    Article
  16. Correlates of healthcare and financial decision making among older adults without dementia.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018
    Article
  17. Religious Orders Study and Rush Memory and Aging Project.Journal of Alzheimer's disease : JAD · 2018
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lei Yu1 Rush University Medical Center, Chicago, IL, USA.
Robert S Wilson1 Rush University Medical Center, Chicago, IL, USA.
S Duke Han1 Rush University Medical Center, Chicago, IL, USA.
Sue Leurgans1 Rush University Medical Center, Chicago, IL, USA.
David A Bennett1 Rush University Medical Center, Chicago, IL, USA.
Patricia A Boyle1 Rush University Medical Center, Chicago, IL, USA.

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Characterizing the Behavior Profile of Healthy Cognitive AgingR01AG034374 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PATRICIA A BOYLE · 2009 to 2026
$8.8M
Epidemiologic Study of Impaired Decision-Making in Preclinical Alzheimer's DiseasR01AG033678 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BOYLE, PATRICIA A · 2009 to 2025
$7.8M
Neural Correlates of Impaired Financial & Health Care Decision-Making in Old AgeK23AG040625 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAN, DUKE · 2012 to 2016
$820k
NIA NIH HHS K23 AG040625NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG033678NIA NIH HHS R01 AG034374
6 · The paper itself

Abstract

objectiveTo quantify longitudinal change in financial and health literacy and examine the associations of declining literacy with incident Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI).

methodData came from 799 participants of an ongoing cohort study. Literacy was measured using a battery of 32 questions. Clinical diagnoses were made annually following uniform structured procedures. The associations of declining literacy with incident AD dementia and MCI were tested using a joint model for longitudinal and time-to-event data.

resultsWe observed an overall decline in total literacy score over up to 6 years of follow-up ( p < .001). Faster decline in literacy was associated with higher risks for incident AD dementia (hazard ratio = 4.526, 95% confidence interval = [2.993, 6.843], p < .001) and incident MCI (hazard ratio = 2.971, 95% confidence interval = [1.509, 5.849], p = .002). DISCUSSION: Declining literacy among community-dwelling older persons predicts adverse cognitive outcomes and serves as an early indicator of impending dementia.

Indexed as

Independent LivingLiteracyAgedAged, 80 and overAlzheimer DiseaseCognitive DysfunctionCohort StudiesFemaleHumansIllinoisLongitudinal StudiesMaleRisk FactorsAD dementiaagingdomain-specific literacymild cognitive impairment

Identifiers

PMID28645223
PMCPMC5869171

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.