Evidence map›Paper›PMID 28645200›Full record

ArticleNeuro-oncology2017

Prognostic awareness, prognostic communication, and cognitive function in patients with malignant glioma.

Eli L Diamond, Holly G Prigerson, Denise C Correa, Anne Reiner, Katherine Panageas, Maria Kryza-Lacombe, Justin Buthorn, Elizabeth C Neil, Alex M Miller, Lisa M DeAngelis and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Eli L DiamondDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Holly G PrigersonDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Denise C CorreaDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Anne ReinerDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Katherine PanageasDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Maria Kryza-LacombeDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Justin ButhornDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Elizabeth C NeilDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Alex M MillerDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Lisa M DeAngelisDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Allison J ApplebaumDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York; Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California; Department of Neurology, University of Minnesota, Minneapolis, Minnesota; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center · USUniversity of Minnesota · USSan Diego State University · USCornell University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Psychosocial Approaches to Better Understanding & End-Stage Cancer Care (PROTECT)R35CA197730 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Holly Gwen Prigerson · 2015 to 2026
$11.2M
NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA197730
6 · The paper itself

Abstract

backgroundMalignant glioma (MG) is a devastating neuro-oncologic disease with almost invariably poor prognosis. Prognostic awareness (PA) is the awareness of incurable disease and shortened life expectancy (LE). Accurate PA is associated with favorable psychological outcomes at the end of life (EoL) for patients with cancer; however, little is known about PA or prognostic communication in MG. Moreover, research has yet to evaluate the impact of cognitive impairment on PA and preferred forms of communication.

methodsFifty MG patients and 32 paired caregivers were evaluated in this exploratory study with a semi-structured PA assessment aimed to measure their awareness of MG incurability and LE. Full PA was defined as awareness of MG incurability and accurate estimate of LE. The assessment included a survey about preferences for prognostic communication (items from the Prognosis and Treatment Perceptions Questionnaire), neurocognitive assessment (Hopkins Verbal Learning Test-Revised, Trail Making Test Parts A and B, and the Controlled Oral Word Association Test), and measurements of mood (Hospital Anxiety and Depression Scale) and quality of life (Functional Assessment of Cancer Therapy-Brain [FACT-Br]).

resultsTwenty (40%) patients and 22 (69%) caregivers had full PA. Thirty (60%) patients and 23 (72%) caregivers reported that prognostic information was extremely or very important, and 21 (42%) patients and 16 (50%) caregivers desired more prognostic information. Patients with memory impairment more frequently believed that prognostic information was important (P = 0.04, P = 0.03) and desired more information (P = 0.05, P = 0.003) as compared with those without impairment.

conclusionsMost MG patients were unaware of their LE. Memory impairment may influence preferences for prognostic information.

Indexed as

CommunicationHealth Knowledge, Attitudes, PracticeQuality of LifeAdolescentAdultAgedAged, 80 and overAttitude to HealthCaregiversCognitionFemaleFollow-Up StudiesGliomaHumansLife ExpectancyMalecommunicationend of lifeglioblastomamalignant brain tumorquality of life

Identifiers

PMID28645200
PMCPMC5737692
OpenAlexW2703019380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.