ArticleNucleic acids research2017
The biogenesis pathway of tRNA-derived piRNAs in Bombyx germ cells.
Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- PIWI-Interacting RNAs in brain health and disease: biogenesis, mechanisms, and therapeutic horizons.Psychopharmacology · 2026Review
- Profile of tRNA-derived short non-coding RNAs during monocyte differentiation and their role in macrophage survival.RNA biology · 2025Article
- Angiogenin-catalyzed cleavage within tRNA anticodon-loops identified by cP-RNA-seq.Bioscience, biotechnology, and biochemistry · 2025Article
- cP-RNA-seq for tRNA half sequencing.Methods in enzymology · 2025Article
- TaqMan RT-qPCR for tRNA half quantification.Methods in enzymology · 2025Article
- Small RNAs in the pathogenesis of preeclampsia.Placenta · 2024Review
- Potential molecular mechanisms and clinical implications of piRNAs in preeclampsia: a review.Reproductive biology and endocrinology : RB&E · 2024Review
- Review
- The tRNAProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers.Genes & diseases · 2024Review
- Small RNAs: An expanding world with therapeutic promises.Fundamental research · 2023Review
- Landscape of Clinically Relevant Exosomal tRNA-Derived Non-coding RNAs.Molecular biotechnology · 2023Review
- Review
- Making Invisible RNA Visible: Discriminative Sequencing Methods for RNA Molecules with Specific Terminal Formations.Biomolecules · 2022Review
- Cloning, Sequencing, and Linkage Analysis of piRNAs.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Small Noncoding RNAs in Reproduction and Infertility.Biomedicines · 2021Review
- Mammalian antiviral systems directed by small RNA.PLoS pathogens · 2021Review
- Origins and evolving functionalities of tRNA-derived small RNAs.Trends in biochemical sciences · 2021Review
- RNase κ promotes robust piRNA production by generating 2',3'-cyclic phosphate-containing precursors.Nature communications · 2021Article
- The biogenesis and biological function of PIWI-interacting RNA in cancer.Journal of hematology & oncology · 2021Review
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Authors and funding
6 authors.
Funding
Abstract
Transfer RNAs (tRNAs) function in translational machinery and further serves as a source of short non-coding RNAs (ncRNAs). tRNA-derived ncRNAs show differential expression profiles and play roles in many biological processes beyond translation. Molecular mechanisms that shape and regulate their expression profiles are largely unknown. Here, we report the mechanism of biogenesis for tRNA-derived Piwi-interacting RNAs (td-piRNAs) expressed in Bombyx BmN4 cells. In the cells, two cytoplasmic tRNA species, tRNAAspGUC and tRNAHisGUG, served as major sources for td-piRNAs, which were derived from the 5'-part of the respective tRNAs. cP-RNA-seq identified the two tRNAs as major substrates for the 5'-tRNA halves as well, suggesting a previously uncharacterized link between 5'-tRNA halves and td-piRNAs. An increase in levels of the 5'-tRNA halves, induced by BmNSun2 knockdown, enhanced the td-piRNA expression levels without quantitative change in mature tRNAs, indicating that 5'-tRNA halves, not mature tRNAs, are the direct precursors for td-piRNAs. For the generation of tRNAHisGUG-derived piRNAs, BmThg1l-mediated nucleotide addition to -1 position of tRNAHisGUG was required, revealing an important function of BmThg1l in piRNA biogenesis. Our study advances the understanding of biogenesis mechanisms and the genesis of specific expression profiles for tRNA-derived ncRNAs.
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