Evidence map›Paper›PMID 28644472›Full record

ArticleNature chemistry2017

Placing and shaping liposomes with reconfigurable DNA nanocages.

Zhao Zhang, Yang Yang, Frederic Pincet, Marc C Llaguno, Chenxiang Lin

Abstract read
In one paragraph

Article in Nature chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed.

  1. Controlling membrane tension by dynamic DNA nanorings.bioRxiv : the preprint server for biology · 2026
    Article
  2. Membrane-Associated Biomolecules for Synthetic Cell Signalling.Chembiochem : a European journal of chemical biology · 2026
    Review
  3. Article
  4. DNA-Lipid Nanodiscs with a Polyethylene Glycol Interface.Journal of the American Chemical Society · 2026
    Article
  5. Article
  6. Reactive oxygen species-resistant ultrastable super-resolution DNA framework dots.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. From toroids to helical tubules: Kirigami-inspired programmable assembly of two-periodic curved crystals from DNA origami.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Programmable Liposome Organization via DNA Origami Templates.Journal of the American Chemical Society · 2025
    Article
  9. DNA-Assisted Assays for Studying Lipid Transfer Between Membranes.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhao ZhangDepartment of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06510, USA.
Yang YangDepartment of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06510, USA.ORCID 0000-0002-2630-6062
Frederic PincetDepartment of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06510, USA.
Marc C LlagunoDepartment of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06510, USA.
Chenxiang LinDepartment of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06510, USA.ORCID 0000-0001-7041-1946

Funding

Cell-free membrane remodeling guided by DNA nano-templatesDP2GM114830 · NIGMS · YALE UNIVERSITY · PI LIN, CHENXIANG · 2014 to 2014
$2.5M
Generating nuclear pore complex mimics with DNA origamiR21GM109466 · NIGMS · YALE UNIVERSITY · PI LIN, CHENXIANG, LUSK, CHARLES PATRICK · 2014 to 2015
$458k
NIGMS NIH HHS DP2 GM114830NIGMS NIH HHS R21 GM109466
6 · The paper itself

Abstract

The diverse structure and regulated deformation of lipid bilayer membranes are among a cell's most fascinating features. Artificial membrane-bound vesicles, known as liposomes, are versatile tools for modelling biological membranes and delivering foreign objects to cells. To fully mimic the complexity of cell membranes and optimize the efficiency of delivery vesicles, controlling liposome shape (both statically and dynamically) is of utmost importance. Here we report the assembly, arrangement and remodelling of liposomes with designer geometry: all of which are exquisitely controlled by a set of modular, reconfigurable DNA nanocages. Tubular and toroid shapes, among others, are transcribed from DNA cages to liposomes with high fidelity, giving rise to membrane curvatures present in cells yet previously difficult to construct in vitro. Moreover, the conformational changes of DNA cages drive membrane fusion and bending with predictable outcomes, opening up opportunities for the systematic study of membrane mechanics.

Indexed as

DNALiposomesNanostructuresDNALiposomes

Identifiers

PMID28644472
PMCPMC5542812

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.