Observational studyJournal of pediatric gastroenterology and nutrition2017
Vitamin D Deficiency Is Not Associated With Growth or the Incidence of Common Morbidities Among Tanzanian Infants.
Observational study in Journal of pediatric gastroenterology and nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- The relationship of vitamin D deficiency and childhood diarrhea: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Association Between Vitamin D Status and Undernutrition Indices in Children: A Systematic Review and Meta-Analysis of Observational Studies.Frontiers in pediatrics · 2021Pooled it
- The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya: A cohort study.Maternal & child nutrition · 2018Trial
- Osteoprotective Effects and In Silico Profiling of Parinari curatellifolia Planch. Ex Benth. (Chrysobalanaceae) Extract on Acute Plasmodium berghei-Compromised Rat Bone.Chemistry & biodiversity · 2026Article
- Article
- Relationships for vitamin D with childhood height growth velocity and low bone mineral density risk.Frontiers in nutrition · 2023Article
- Vitamin D deficiency among apparently healthy children and children with common medical illnesses in Sub-Saharan Africa: A systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2022Review
- Article
- Prevalence and predictors of vitamin D deficiency in young African children.BMC medicine · 2021Article
- Prevalence and Correlates of Vitamin D Deficiency among Young South African Infants: A Birth Cohort Study.Nutrients · 2021Article
- Vitamin D Status and Its Influence on the Health of Preschool Children in Hangzhou.Frontiers in public health · 2021Article
- The incidence of acute respiratory infection in Indonesian infants and association with vitamin D deficiency.PloS one · 2021Article
- Vitamin D Status Is Not Associated with Cognitive or Motor Function in Pre-School Ugandan Children.Nutrients · 2020Article
- Vitamin D status, nutrition and growth in HIV-infected mothers and HIV-exposed infants and children in Botswana.PloS one · 2020Article
- Birth size and early pneumonia predict linear growth among HIV-exposed uninfected infants.Maternal & child nutrition · 2019Article
- Vitamin D and growth hormone in children: a review of the current scientific knowledge.Journal of translational medicine · 2019Review
- Vitamin D in malaria: more hypotheses than clues.Heliyon · 2019Review
Corrections and comments
- Commented on by
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe objective of this study was to examine risk factors for vitamin D deficiency and determine the association of vitamin D status with child growth and incidence of common morbidities among Tanzanian infants.
methodsA prospective cohort of 581 Tanzanian infants born to human immunodeficiency virus (HIV)-uninfected mothers had serum 25-hydroxyvitamin D assessed at 6 weeks and 6 months of age. Infants were seen at monthly clinic visits for growth monitoring until 18 months of age. Physicians examined infants every 3 months or when an illness was noted to document morbidities.
resultsThe prevalence of vitamin D deficiency (<20 ng/mL) declined from 76.4% at 6 weeks of age to 21.2% at 6 months. Infants who were exclusively breastfed at 6 weeks of age had 2.05 (95% confidence interval 1.11-3.79; P = 0.02) times the risk of vitamin D deficiency as compared formula-fed infants. After multivariate adjustment, there was no association of vitamin D status at 6 weeks or 6 months with the incidence of stunting, wasting, or underweight. There was also no association of low vitamin D with the incidence of diarrhea, upper respiratory infection, acute lower respiratory tract infection, or malaria.
conclusionsVitamin D deficiency is common during early infancy, particularly among exclusively breastfed infants; however, these observational data suggest it may not be an important contributor to morbidity and growth among the general population of Tanzanian infants. Future studies of vitamin D among high-risk infants, including those with low birthweight and exposed to HIV, may be warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.