Evidence map›Paper›PMID 28644348›Full record

Trial reportJournal of pediatric gastroenterology and nutrition2017

Biomarkers of Environmental Enteric Dysfunction Among Children in Rural Bangladesh.

Rebecca K Campbell, Kerry J Schulze, Saijuddin Shaikh, Sucheta Mehra, Hasmot Ali, Lee Wu, Rubhana Raqib, Sarah Baker, Alain Labrique, Keith P West and 1 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pediatric gastroenterology and nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  14. A cross-sectional study of associations between theThe American journal of clinical nutrition · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Rebecca K Campbell*Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD †JiVitA Project, Gaibandha, Bangladesh ‡icddr,b, Mohakhali, Dhaka, Bangladesh.
Kerry J Schulze
Saijuddin Shaikh
Sucheta Mehra
Hasmot Ali
Lee Wu
Rubhana Raqib
Sarah Baker
Alain Labrique
Keith P West
Parul Christian
Johns Hopkins University · USInternational Centre for Diarrhoeal Disease Research · BD

Funding

Lipid based complementary foods and gut health in young childrenR21HD081503 · NICHD · JOHNS HOPKINS UNIVERSITY · PI SCHULZE, KERRY JEAN · 2015 to 2016
$445k
NICHD NIH HHS R21 HD081503
6 · The paper itself

Abstract

objectivesEnvironmental enteric dysfunction (EED) may inhibit growth and development in low- and middle-income countries, but available assessment methodologies limit its study. In rural Bangladesh, we measured EED using the widely used lactulose mannitol ratio (L:M) test and a panel of intestinal and systemic health biomarkers to evaluate convergence among biomarkers and describe risk factors for EED.

methodsIn 539 18-month-old children finishing participation in a randomized food supplementation trial, serum, stool, and urine collected after lactulose and mannitol dosing were analyzed for biomarkers of intestinal absorption, inflammation, permeability and repair, and systemic inflammation. EED scores for each participant were developed using principal component analysis and partial least squares regression. Associations between scores and L:M and with child sociodemographic and health characteristics were evaluated using regression analysis.

resultsEED prevalence (L:M > 0.07) was 39.0%; 60% had elevated acute phase proteins (C-reactive protein >5 mg/L or α-1 acid glycoprotein >100 mg/dL). Correlations between intestinal biomarkers were low, with the highest between myeloperoxidase and α-1 antitrypsin (r = 0.33, P < 0.01), and biomarker values did not differ by supplementation history. A 1-factor partial least squares model with L:M as the dependent variable explained only 8.6% of L:M variability. In adjusted models, L:M was associated with child sex and socioeconomic status index, whereas systemic inflammation was predicted mainly by recent illness, not EED.

conclusionsImpaired intestinal health is widespread in this setting of prevalent stunting, but a panel of serum and stool biomarkers demonstrated poor agreement with L:M. Etiologies of intestinal and systemic inflammation are likely numerous and complex in resource-poor settings, underscoring the need for a better case definition with corresponding diagnostic methods to further the study of EED.

Indexed as

Developing CountriesRural HealthBangladeshBiomarkersFemaleHumansInfantIntestinal AbsorptionIntestinal DiseasesIntestinal MucosaLeast-Squares AnalysisMalePermeabilityPrevalencePrincipal Component AnalysisTreatment OutcomeBiomarkers

Identifiers

PMID28644348
PMCPMC5492885
OpenAlexW2594704520

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.