Evidence map›Paper›PMID 28644125›Full record

ArticleeLife2017

Exploiting CRISPR-Cas to manipulate

Karthik Hullahalli, Marinelle Rodrigues, Kelli L Palmer

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Avian PathogenicVeterinary sciences · 2025
    Review
  4. Hidden diversity inMicrobiology spectrum · 2025
    Article
  5. Review
  6. CRISPR-Cas systems in enterococci.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Review
  7. Article
  8. CRISPR-Cas System: A New Dawn to Combat Antibiotic Resistance.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2024
    Review
  9. Review
  10. Article
  11. CRISPR-Based Gene Editing inPharmaceuticals (Basel, Switzerland) · 2023
    Review
  12. Article
  13. Vancomycin Resistance inMicroorganisms · 2022
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Role of CRISPR-Cas system on antibiotic resistance patterns of Enterococcus faecalis.Annals of clinical microbiology and antimicrobials · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Karthik HullahalliDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, United States.ORCID 0000-0003-3064-2090
Marinelle RodriguesDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, United States.ORCID 0000-0002-5509-605X
Kelli L PalmerDepartment of Biological Sciences, The University of Texas at Dallas, Richardson, United States.ORCID 0000-0002-7343-9271
The University of Texas at Dallas · US

Funding

Genome defense and acquired antibiotic resistance in Enterococcus faecalis and Enterococcus faeciumR01AI116610 · NIAID · UNIVERSITY OF TEXAS DALLAS · PI PALMER, KELLI LEA · 2015 to 2019
$1.9M
6 · The paper itself

Abstract

CRISPR-Cas provides a barrier to horizontal gene transfer in prokaryotes. It was previously observed that functional CRISPR-Cas systems are absent from multidrug-resistant (MDR)

Indexed as

CRISPR-Cas SystemsEvolution, MolecularDrug Resistance, Multiple, BacterialEnterococcus faecalisGenetic FitnessSelection, Geneticantibiotic resistanceCRISPREnterococcus faecalisevolutionary biologygenomicsinfectious diseasemicrobiologyplasmid

Identifiers

PMID28644125
PMCPMC5491264
OpenAlexW2693250557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.