ArticleAmerican journal of respiratory and critical care medicine2017
Hypoxic Pulmonary Vasoconstriction Does Not Explain All Regional Perfusion Redistribution in Asthma.
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Advances in pulmonary neuroendocrine cells and their cellular interactions in asthma pathogenesis.Frontiers in pharmacology · 2025Review
- Lung functional imaging.Breathe (Sheffield, England) · 2023Article
- The effects of benralizumab on airway geometry and dynamics in severe eosinophilic asthma: a single-arm study design exploring a functional respiratory imaging approach.Respiratory research · 2023Article
- Perfusion imaging heterogeneity during NO inhalation distinguishes pulmonary arterial hypertension (PAH) from healthy subjects and has potential as an imaging biomarker.Respiratory research · 2022Article
- Chest dual-energy CT to assess the effects of steroids on lung function in severe COVID-19 patients.Critical care (London, England) · 2022Observational
- Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.Journal of biomechanical engineering · 2022Article
- Dysregulation of the Nitric Oxide/Dimethylarginine Pathway in Hypoxic Pulmonary Vasoconstriction-Molecular Mechanisms and Clinical Significance.Frontiers in medicine · 2022Review
- PET Imaging Reveals Early Pulmonary Perfusion Abnormalities in HIV Infection Similar to Smoking.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Article
- Altered airway mechanics in the context of obesity and asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Children with uncontrolled asthma and significant reversibility might show hypoxaemia.European journal of pediatrics · 2020Observational
- Perfusion Imaging Distinguishes Exercise Pulmonary Arterial Hypertension at Rest.American journal of respiratory and critical care medicine · 2019Article
- Prominent Bronchopulmonary Vascular Anastomoses in Fatal Childhood Asthma.Annals of the American Thoracic Society · 2018Article
- Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort.American journal of respiratory and critical care medicine · 2018Article
- Spatial persistence of reduced specific ventilation following methacholine challenge in the healthy human lung.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Reply to Dorrington et al. and to Swenson: "Hypercapnic Pulmonary Vasoconstriction Contributes to Regional Perfusion Distribution: Relevance to Asthma" and "Hypercapnic Pulmonary Vasoconstriction as a Mechanism for Regional Perfusion Redistribution in Asthma".American journal of respiratory and critical care medicine · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleRegional hypoventilation in bronchoconstricted patients with asthma is spatially associated with reduced perfusion, which is proposed to result from hypoxic pulmonary vasoconstriction (HPV).
objectivesTo determine the role of HPV in the regional perfusion redistribution in bronchoconstricted patients with asthma.
methodsEight patients with asthma completed positron emission tomographic/computed tomographic lung imaging at baseline and after bronchoconstriction, breathing either room air or 80% oxygen (80% O MEASUREMENTS AND MAIN
resultsIn the sV
conclusionsHPV is not the only mechanism that contributes to perfusion redistribution in bronchoconstricted patients with asthma, suggesting that another nonhypoxia mechanism also contributes. We propose that this nonhypoxia mechanism may be either direct mechanical interactions and/or unidentified intercellular signaling between constricted airways, the parenchyma, and the surrounding vasculature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.