Evidence map›Paper›PMID 28644039›Full record

ArticleBiomarkers in medicine2017

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program.

Katrina Gwinn, Karen K David, Christine Swanson-Fischer, Roger Albin, Coryse St Hillaire-Clarke, Beth-Anne Sieber, Codrin Lungu, F DuBois Bowman, Roy N Alcalay, Debra Babcock and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarkers in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Guidelines for the standardized collection of blood-based biomarkers in psychiatry: Steps for laboratory validity - a consensus of the Biomarkers Task Force from the WFSBP.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2019
    Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 18 institutions in 1 country.

Katrina GwinnNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD, USA.
Karen K DavidNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD, USA.
Christine Swanson-FischerNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD, USA.
Roger AlbinNeurology Service & GRECC, VAAAHS, UM Udall Center, University of Michigan, Ann Arbor, MI, USA.
Coryse St Hillaire-ClarkeNational Institute on Aging, NIH, Bethesda, MD, USA.
Beth-Anne SieberNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD, USA.
Codrin LunguNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD, USA.
F DuBois BowmanDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
Roy N AlcalayDepartment of Neurology, Columbia University, New York, NY, USA.
Debra BabcockNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD, USA.
Ted M DawsonNeuroregeneration & Stem Cell Programs, Institute for Cell Engineering, Solomon H Snyder Department of Neuroscience, Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Richard B DeweyDepartment of Neurology & Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tatiana ForoudDepartment of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Dwight GermanDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xuemei HuangDepartment of Neurology, Penn State Hershey Medical Center, Hershey, PA, USA.
Vlad PetyukBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Judith A PotashkinDepartment of Cellular & Molecular Pharmacology, Rosalind Franklin University of Medicine & Science, North Chicago, IL, USA.
Rachel Saunders-PullmanDepartment of Neurology, Mount Sinai Beth Israel & Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Margaret SutherlandNational Institute of Neurological Disorders & Stroke, National Institutes of Health, Bethesda, MD, USA.
David R WaltDepartment of Chemistry, Tufts University, Medford, MA, USA.
Andrew B WestDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jing ZhangDepartment of Pathology, University of Washington, Seattle, WA, USA.
Alice Chen-PlotkinDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Clemens R ScherzerDepartment of Neurology, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA, USA.
David E VaillancourtDepartments of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, USA.
Liana S RosenthalDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
National Institute of Neurological Disorders and Stroke · USNational Institutes of Health · USColumbia University · USJohns Hopkins University · USThe University of Texas Southwestern Medical Center · USHarvard University · USIcahn School of Medicine at Mount Sinai · USIndiana University School of MedicineNational Institute on Aging · USPacific Northwest National Laboratory · USPenn State Milton S. Hershey Medical Center · USRosalind Franklin University of Medicine and Science · USTufts University · USUniversity of Alabama at Birmingham · USUniversity of Florida · USUniversity of Pennsylvania · USUniversity of Washington · USVA Ann Arbor Healthcare System · US

Funding

Understanding Mechanisms of a-synuclein pathologyP50NS038377 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DAWSON, TED M. · 1998 to 2019
$38.8M
Project IV: "Alpha-Synuclein Strains & Diverse Synucleinopathies"P50NS053488 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TROJANOWSKI, JOHN Q. · 2007 to 2017
$20.9M
Udall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3M
NINDS Biomarker RepositoryU24NS095871 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI TATIANA M. FOROUD · 2015 to 2026
$18.3M
Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
Mechanisms of LRRK2 Mediated NeurotoxicityR01NS064934 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEST, ANDREW B · 2010 to 2025
$6.3M
PENN STATE CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033184 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2011 to 2011
$4.5M
Multimodal MRI Markers of Nigrostriatal Pathology in Parkinson's DiseaseU01NS082151 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2012 to 2016
$4.2M
Johns Hopkins Medicine Biomarker Discovery in Parkinson's DiseaseU01NS082133 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DAWSON, TED M. · 2012 to 2016
$4.1M
Diagnostic and prognostic biomarkers for Parkinsons diseaseU01NS082148 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI DEWEY, RICHARD B, GERMAN, DWIGHT C. · 2012 to 2016
$3.0M
GBA pathway markers for Lewy body dementiasU01NS100603 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHERZER, CLEMENS R · 2016 to 2020
$2.9M
NCATS NIH HHS UL1 TR000127NCRR NIH HHS UL1 RR033184NINDS NIH HHS K02 NS080915NINDS NIH HHS P20 NS092530NINDS NIH HHS P50 NS038377NINDS NIH HHS P50 NS053488NINDS NIH HHS P50 NS062684NINDS NIH HHS P50 NS091856NINDS NIH HHS R01 NS064934NINDS NIH HHS R33 NS097643NINDS NIH HHS R56 NS082941NINDS NIH HHS U01 NS082080NINDS NIH HHS U01 NS082133NINDS NIH HHS U01 NS082134NINDS NIH HHS U01 NS082148NINDS NIH HHS U01 NS082151NINDS NIH HHS U01 NS082157NINDS NIH HHS U01 NS094148NINDS NIH HHS U01 NS095736NINDS NIH HHS U01 NS097028NINDS NIH HHS U01 NS097037NINDS NIH HHS U01 NS097056NINDS NIH HHS U01 NS100603NINDS NIH HHS U18 NS082140NINDS NIH HHS U24 NS095871
6 · The paper itself

Abstract

Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's Disease Biomarker Program (PDBP) and other mechanisms, no single PD marker or set of markers are ready for clinical use. Here we discuss the current state of biomarker discovery for platforms relevant to PDBP. We discuss the role of the PDBP in PD biomarker identification and present guidelines to facilitate their development. These guidelines include: harmonizing procedures for biofluid acquisition and clinical assessments, replication of the most promising biomarkers, support and encouragement of publications that report negative findings, longitudinal follow-up of current cohorts including the PDBP, testing of wearable technologies to capture readouts between study visits and development of recently diagnosed (de novo) cohorts to foster identification of the earliest markers of disease onset.

Indexed as

National Institute of Neurological Disorders and Stroke (U.S.)BiomarkersCohort StudiesHumansParkinson DiseaseUnited StatesBiomarkersbiomarkersNINDSParkinson's diseasePDBP

Identifiers

PMID28644039
PMCPMC5619098
OpenAlexW2692583471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.