Evidence map›Paper›PMID 28643924›Full record

ReviewOrthodontics & craniofacial research2017

Exosomes: novel regulators of bone remodelling and potential therapeutic agents for orthodontics.

L S Holliday, K P McHugh, J Zuo, J I Aguirre, J K Neubert, W J Rody

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Orthodontics & craniofacial research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Effect of primary osteoblast-derived extracellular vesicles on osteoclast differentiation.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Observational
  12. Article
  13. Review
  14. Review
  15. Review
  16. Regulation of osteoclast-mediated bone resorption by microRNA.Cellular and molecular life sciences : CMLS · 2022
    Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

L S HollidayDepartment of Orthodontics, University of Florida College of Dentistry, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-0844-1965
K P McHughDepartment of Periodontics, University of Florida College of Dentistry, Gainesville, FL, USA.
J ZuoDepartment of Orthodontics, University of Florida College of Dentistry, Gainesville, FL, USA.
J I AguirreDepartment of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL, USA.
J K NeubertDepartment of Orthodontics, University of Florida College of Dentistry, Gainesville, FL, USA.ORCID http://orcid.org/0000-0001-6774-3093
W J RodyDepartment of Orthodontics, University of Florida College of Dentistry, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-5496-7642
University of Florida · US

Funding

Exosomes in Alveolor Bone Remodeling and Root ResorptionR21DE023900 · NIDCR · UNIVERSITY OF FLORIDA · PI HOLLIDAY, LEXIE SHANNON · 2014 to 2015
$413k
Dental applications for a novel osteoclast inhibitorR21DE019862 · NIDCR · UNIVERSITY OF FLORIDA · PI HOLLIDAY, LEXIE SHANNON · 2010 to 2011
$401k
NIDCR NIH HHS R21 DE019862NIDCR NIH HHS R21 DE023900
6 · The paper itself

Abstract

Recent studies suggest that exosomes are involved in intercellular communication required for the maintenance of healthy bone. Exosomes are small (30-150 nm in diameter) extracellular vesicles that are formed in multivesicular bodies and are released from cells as the multivesicular bodies fuse with the plasma membrane. Regulatory exosomes have the capacity to exert profound control over target cells. They can stimulate plasma membrane receptors and are also internalized by the target cell delivering proteins, lipids, small molecules and functional RNAs from the cell of origin. We and others have recently reported on regulatory exosomes from osteoclasts and osteoblasts. Key candidate molecules identified in exosome-based regulation of bone remodelling include receptor activator of nuclear factor kappa B (RANK), RANK-ligand (RANKL), ephrinA2, semaphorin 4D, microRNA-146a and microRNA- 214-3p. Exosomes will likely prove to be crucial elements in the communication networks integrating bone cells (osteoclasts, osteoblasts, osteocytes) and linking bone to other tissue. Exosomes collected from bone cells grown in culture may prove useful to augment bone remodelling associated with orthodontic force application or required for the repair of craniofacial bone. Various technologies allow exosomes to be engineered to improve their targeting and efficacy for therapeutic purposes. In summary, exosomes have emerged as important elements of the machinery for intercellular communication between bone cells. They hold great promise as therapeutic targets, biomarkers and therapeutic agents for orthodontists.

Indexed as

OrthodonticsAnimalsAntigens, CDBone RemodelingCell CommunicationEphrin-A2ExosomesHumansMicroRNAsOsteoblastsOsteoclastsRANK LigandReceptor Activator of Nuclear Factor-kappa BSemaphorinsAntigens, CDCD100 antigenEphrin-A2MicroRNAsRANK LigandReceptor Activator of Nuclear Factor-kappa BSemaphorinsextracellular vesiclemicrovesicleosteoblastosteoclastRANK

Identifiers

PMID28643924
PMCPMC5484069
OpenAlexW2653323744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.