ArticleOrthodontics & craniofacial research2017
The use of cell culture platforms to identify novel markers of bone and dentin resorption.
Article in Orthodontics & craniofacial research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Metabolites From Salivary Exosomes as Potential Biomarkers for Alveolar Bone and Tooth Resorption.Orthodontics & craniofacial research · 2025Article
- Metabolomic signatures distinguish extracellular vesicles from osteoclasts and odontoclasts.Orthodontics & craniofacial research · 2023Article
- Receptor activator of nuclear factor-kappa B is enriched in CD9-positive extracellular vesicles released by osteoclasts.Extracellular vesicles and circulating nucleic acids · 2023Article
- Article
- The proteome of extracellular vesicles released by clastic cells differs based on their substrate.PloS one · 2019Article
- Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes.Arthritis research & therapy · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectives1) To test the hypothesis that there would be proteomic differences in the composition of exosomes isolated from osteoclasts and odontoclasts and 2) to determine the clinical usefulness of these in vitro biomarker candidates. MATERIALS AND
methodsMouse bone marrow-derived precursors were cultured on either dentin or bone slices and allowed to mature and begin resorption. Exosomes were isolated from cell culture media and characterized by mass spectrometry. The proteomic data obtained from this in vitro study were compared with the data obtained from human samples in our previous work.
resultsThere was a difference in the proteomic composition of exosomes from osteoclasts and odontoclasts. A total of 40 exosomal proteins were only present in osteoclast media, whereas six unique exosomal proteins were identified in odontoclast supernatants. Approximately 50% of exosomal proteins released by clastic cells in vitro can be found in oral fluids.
conclusionOur data suggest that the mineralized matrix type plays a role in the final phenotypic characteristics of mouse clastic cells. Many in vitro biomarker candidates of bone and dentin resorption can also be found in human oral fluids, thus indicating that this approach may be a viable alternative in biomarker discovery.
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Registered trials
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