ArticleOrthodontics & craniofacial research2017
Diverse contribution of Col2a1-expressing cells to the craniofacial skeletal cell lineages.
Article in Orthodontics & craniofacial research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
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- MyD88 in osteoclast and osteoblast lineages differentially controls bone remodeling in homeostasis and malaria.International immunology · 2024Article
- The Contribution of Meckel's Cartilage-Derived Type II Collagen-Positive Cells to the Jawbone Development and Repair.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024Article
- Sfrp4 is required to maintain Ctsk-lineage periosteal stem cell niche function.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Control of craniofacial development by the collagen receptor, discoidin domain receptor 2.eLife · 2023Article
- Type II collagen-positive progenitors are important stem cells in controlling skeletal development and vascular formation.Bone research · 2022Article
- The Emerging Role of Cell Transdifferentiation in Skeletal Development and Diseases.International journal of molecular sciences · 2022Review
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- The diverse origin of bone-forming osteoblasts.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Review
- Septal chondrocyte hypertrophy contributes to midface deformity in a mouse model of Apert syndrome.Scientific reports · 2021Article
- The Skull's Girder: A Brief Review of the Cranial Base.Journal of developmental biology · 2021Review
- The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification.Bone research · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesCraniofacial skeletal development requires deliberate coordination of two distinct mechanisms of endochondral and intramembranous ossification. Col2a1-expressing cells encompass growth-associated skeletal progenitors in endochondral bones of the limb. The objective of this study was to determine the contribution of Col2a1-expressing cells to the craniofacial skeletal cell lineages. We hypothesize that Col2a1-expressing progenitors significantly contribute to various modes of ossification associated with the craniofacial development.
methodsCellular fates of Col2a1-expressing cells were studied based on a cre-loxP system using a Col2a1-cre transgene and an R26R-tdTomato reporter allele. We analysed three distinct locations of the craniofacial skeletal complex representing unique ossification mechanisms: the cranial base, the calvaria and the mandibular condyle.
resultsCol2a1-cre consistently marked a majority of skeletal cells in the cranial base. Interestingly, Col2a1-cre also marked a large number of osteoblasts and suture mesenchymal cells in the calvaria, in addition to chondrocytes in the underlying transient cartilage. In the mandibular condyle, Col2a1-cre marked chondrocytes and osteoblasts only during the growth phase.
conclusionsCol2a1 is expressed by progenitors of the skeletal lineage in canonical endochondral bone formation occurring in the cranial base. In contrast, other ossification mechanisms of the craniofacial complex utilize Col2a1-expressing cells in a different manner, whereby Col2a1 may be expressed in more differentiated or transient cell types of the skeletal lineage.
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