ReviewMicrobiology spectrum2017
Lung Microbiota and Its Impact on the Mucosal Immune Phenotype.
Review in Microbiology spectrum, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Reduction of palmitoleic acid due to changes in pulmonary microbiota contributes to acute lung injury after single-lung ventilation.American journal of respiratory cell and molecular biology · 2026Article
- Cystic fibrosis-related diabetes is associated with reduced airway microbial diversity.Respiratory research · 2026Article
- The Lung Microbiome and Its Impact on Obstructive Sleep Apnea: A Diagnostic Frontier.Diagnostics (Basel, Switzerland) · 2025Review
- The intricate interplay among microbiota, mucosal immunity, and viral infection in the respiratory tract.Journal of translational medicine · 2025Review
- Lung Microbiota: From Healthy Lungs to Development of Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2025Review
- Optimization of lung tissue pre-treatment by bead homogenization for subsequent culturomics.Scientific reports · 2024Article
- Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment.Frontiers in microbiology · 2024Review
- Lung Microbiota: Its Relationship to Respiratory System Diseases and Approaches for Lung-Targeted Probiotic Bacteria Delivery.Molecular pharmaceutics · 2023Review
- Pulmonary microbiota intervention alleviates fine particulate matter-induced lung inflammation in broilers.Journal of animal science · 2023Article
- Host microbiome in tuberculosis: disease, treatment, and immunity perspectives.Frontiers in microbiology · 2023Review
- Bacterial infection and microbiota in carcinogenesis and tumor development.Frontiers in cellular and infection microbiology · 2023Review
- Commensal bacteria of the lung microbiota synergistically inhibit inflammation in a three-dimensional epithelial cell model.Frontiers in immunology · 2023Article
- Article
- The Airway Microbiota Signatures of Infection and Rejection in Lung Transplant Recipients.Microbiology spectrum · 2022Article
- Article
- Airway Administration of Bacterial Lysate OM-85 Protects Mice Against Respiratory Syncytial Virus Infection.Frontiers in immunology · 2022Article
- Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome.Journal of oral microbiology · 2022Article
- Olmesartan Attenuates Single-Lung Ventilation Induced Lung InjuryFrontiers in pharmacology · 2022Article
- Multi-omics analysis of respiratory specimen characterizes baseline molecular determinants associated with SARS-CoV-2 outcome.iScience · 2021Article
- Lower airway microbiota in children with Down syndrome compared to controls with similar respiratory symptomatology.Translational pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The use of culture-independent techniques has allowed us to appreciate that the upper and lower respiratory tract contain a diverse community of microbes in health and disease. Research has only recently explored the effects of the microbiome on the host immune response. The exposure of the human body to the bacterial environment is an important factor for immunological development; thus, the interaction between the microbiome and its host is critical to understanding the pathogenesis of disease. In this article, we discuss the mechanisms that determine the composition of the airway microbiome and its effects on the host immune response. With the use of ecological principles, we have learned how the lower airways constitute a unique niche subjected to frequent microbial migration (e.g., through aspiration) and constant immunological pressure. The discussion will focus on the possible inflammatory pathways that are up- and downregulated when the immune system is challenged by dysbiosis. Identification of potential markers and microbial targets to address the modulation of inflammation in early disease, when changes may have the most effect, will be critical for future therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.