ArticleAIDS care2018
Distinctive barriers to antiretroviral therapy adherence among non-adherent adolescents living with HIV in Botswana.
Article in AIDS care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Impact of HIV-Related Stigma on Antiretroviral Therapy Adherence, Engagement and Retention in HIV Care, and Transition to Adult HIV Care in Pediatric and Young Adult Populations Living With HIV: A Literature Review.AIDS and behavior · 2025Pooled it
- A Booklet Self-Help Intervention for People Living with HIV and Depressive Symptoms in Botswana: A Randomized Controlled Trial.AIDS and behavior · 2025Trial
- A Cluster-Randomized Controlled Trial of an Economic Strengthening Intervention to Enhance Antiretroviral Therapy Adherence among Adolescents Living with HIV.AIDS and behavior · 2024Trial
- A group-based mental health intervention for young people living with HIV in Tanzania: results of a pilot individually randomized group treatment trial.BMC public health · 2020Trial
- Childhood Maltreatment and Psychological Distress Among Adolescents and Young Adults Living with HIV in Zimbabwe.Journal of child & adolescent trauma · 2026Article
- Longitudinal patterns and predictors of opioid and stimulant use initiation and cessation among female sex workers living with HIV in South Africa.Drug and alcohol dependence · 2025Article
- Exploring the drivers of adolescent sexual and reproductive healthcare-seeking behavior in northwestern Botswana: a cross-sectional analysis.BMC public health · 2025Article
- Enhancing engagement in HIV care among adolescents and young adults: A focus on phone-based navigation and relationship building to address barriers in HIV care.PLOS global public health · 2025Article
- Article
- Implementation Determinants of Problem-Solving Therapy Delivered by Near-Peer Lay Counselors for Youth Living with HIV in Botswana: Lay Counsellor Perspectives.Global implementation research and applications · 2024Article
- Association between Childhood Trauma, Mental Health Symptoms and Adherence Among Youth Living with HIV in Botswana.Journal of child & adolescent trauma · 2024Article
- Youth perspectives of working with near peer youth lay counsellors: The Safe Haven Pilot.Journal of community psychology · 2023Article
- Factors Associated With Viral Suppression and Drug Resistance in Children and Adolescents Living With HIV in Care and Treatment Programs in Southern Tanzania.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Symptoms of depression, anxiety, and thoughts of suicide/self-injury in adolescents and young adults living with HIV in Botswana.African journal of AIDS research : AJAR · 2023Article
- Article
- Challenges and coping strategies among young adults living with perinatally acquired HIV infection in Botswana. A qualitative study.PloS one · 2023Article
- Storyboarding HIV Infected Young People's Adherence to Antiretroviral Therapy in Lower- to Upper Middle-Income Countries: A New-Materialist Qualitative Evidence Synthesis.International journal of environmental research and public health · 2022Review
- Determinants of health-related quality of life in young adults living with perinatally acquired HIV infection in Botswana.Southern African journal of HIV medicine · 2022Article
- Article
- Nonadherence and unsuppressed viral load across adolescence among US youth with perinatally acquired HIV.AIDS (London, England) · 2019Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Levels of adherence to HIV treatment are lower among adolescents compared with older and younger individuals receiving similar therapies. We purposely sampled the most and least adherent adolescents from a 300-adolescent longitudinal HIV treatment adherence study in Gaborone, Botswana. Multiple objective and subjective measures of adherence were available and study participants were selected based on sustained patterns of either excellent or poor adherence over a one-year period. Focus group discussions (FGD) and in-depth interviews (IDI) were conducted with the adolescents and a subset of their caregivers with the goal of revealing barriers and facilitators of adherence. Focus groups were segregated by adherence classification of the participants. Following coding of transcripts, matrices were developed based on participants' adherence classifications in order to clarify differences in themes generated by individuals with different adherence characteristics. 47 adolescents and 25 adults were included. The non-adherent adolescents were older than the adherent adolescents (median age 18 years (IQR 16-19) vs. 14 years (IQR 12-15 years)), with median time on treatment near 10 years in both groups. Interference with daily activities, concerns about stigma and discrimination, side effects, denial of HIV status, and food insecurity arose as challenges to adherence among both those who were consistently adherent and those who were poorly-adherent to their medications. Low outcome expectancy, treatment fatigue, mental health and substance use problems, and mismatches between desired and received social support were discussed only among poorly adherent adolescents and their caregivers. Challenges raised only among adolescents and caregivers in the non-adherent groups are hypothesis-generating, identifying areas that may have a greater contribution to poor outcomes than challenges faced by both adherent and non-adherent adolescents. The contribution of these factors to poor outcomes should be explored in future studies.
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Registered trials
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