ArticleMagnetic resonance in medicine2018
Ultra-short echo time images quantify high liver iron.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Comparison of hepatic iron quantification by MRI between 1.5 and 3 T, using different methods and conversion formulas.European radiology · 2026Article
- Impact of particle size onMagnetic resonance in medicine · 2025Article
- State-of-the-Art Quantification of Liver Iron With MRI-Vendor Implementation and Available Tools.Journal of magnetic resonance imaging : JMRI · 2025Review
- Practical approach to quantitative liver and pancreas MRI in children.Pediatric radiology · 2025Review
- Free-breathing MRI techniques for fat and RMagma (New York, N.Y.) · 2024Review
- Assessing the accuracy of CMRtools software for diagnosing liver iron overload in thalassemia patients: influencing factors and optimisation strategies.Frontiers in medicine · 2024Article
- Simulation of a virtual liver iron overload model and RNMR in biomedicine · 2023Article
- Free-breathing high isotropic resolution quantitative susceptibility mapping (QSM) of liver using 3D multi-echo UTE cones acquisition and respiratory motion-resolved image reconstruction.Magnetic resonance in medicine · 2023Article
- Quantitative MRI of diffuse liver diseases: techniques and tissue-mimicking phantoms.Magma (New York, N.Y.) · 2023Review
- High-resolution 3D ultra-short echo time MRI with Rosette k-space pattern for brain iron content mapping.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023Article
- Quantification of Liver Iron Overload with MRI: Review and Guidelines from the ESGAR and SAR.Radiology · 2023Review
- Ultra-short TMagnetic resonance in medicine · 2023Article
- Biopsy-based optimization and calibration of a signal-intensity-ratio-based MRI method (1.5 Tesla) in a dextran-iron loaded mini-pig model, enabling estimation of very high liver iron concentrations.Magma (New York, N.Y.) · 2022Article
- Hepatic Iron Quantification Using a Free-Breathing 3D Radial Gradient Echo Technique and Validation With a 2D Biopsy-Calibrated RJournal of magnetic resonance imaging : JMRI · 2022Article
- Pituitary Volume and Iron Overload Evaluation by 3T MRI in Thalassemia.Indian journal of pediatrics · 2021Article
- Quantitative magnetic resonance imaging for chronic liver disease.The British journal of radiology · 2021Review
- Free-breathingMagnetic resonance in medicine · 2021Article
- Complex confounder-corrected R2* mapping for liver iron quantification with MRI.European radiology · 2021Article
- Real-World Experience Measurement of Liver Iron Concentration by R2 vs. R2 Star MRI in Hemoglobinopathies.Diagnostics (Basel, Switzerland) · 2020Article
- A hybrid (iron-fat-water) phantom for liver iron overload quantification in the presence of contaminating fat using magnetic resonance imaging.Magma (New York, N.Y.) · 2020Article
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6 authors.
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Abstract
purpose1.5T gradient echo-based R2∗ estimates are standard-of-care for assessing liver iron concentration (LIC). Despite growing popularity of 3T, echo time (TE) limitations prevent 3T liver iron quantitation in the upper half of the clinical range (LIC ⪆20 mg/g). In this work, a 3D radial pulse sequence was assessed to double the dynamic range of 3T LIC estimates. THEORY AND
methodsThe minimum TE limits the dynamic range of pulse sequences to estimate R2∗. 23 chronically-transfused human volunteers were imaged with 1.5T Cartesian gradient echo (1.5T-GRE), 3T Cartesian gradient echo (3T-GRE), and 3T ultrashort TE radial (3T-UTE) pulse sequences; minimum TEs were 0.96, 0.76, and 0.19 ms, respectively. R2∗ was estimated with an exponential signal model, normalized to 1.5T equivalents, and converted to LIC. Bland-Altman analysis compared 3T-based estimates to 1.5T-GRE.
resultsLIC by 3T-GRE was unbiased versus 1.5T-GRE for LIC ≤ 25 mg/g (sd = 9.6%); 3T-GRE failed to quantify LIC > 25 mg/g. At high iron loads, 3T-UTE was unbiased (sd = 14.5%) compared to 1.5T-GRE. Further, 3T-UTE estimated LIC up to 50 mg/g, exceeding 1.5T-GRE limits.
conclusion3T-UTE imaging can reliably estimate high liver iron burdens. In conjunction with 3T-GRE, 3T-UTE allows clinical LIC estimation across a wide range of liver iron loads. Magn Reson Med 79:1579-1585, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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