ArticleCell stress & chaperones2017
Serum histones as biomarkers of the severity of heatstroke in dogs.
Article in Cell stress & chaperones, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Heatstroke-Induced Inflammatory Response and Therapeutic Biomarkers.Biomedicines · 2025Review
- Nafamostat mesylate augments survival in rats afflicted by exertional heat stroke.Frontiers in pharmacology · 2025Article
- The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury.Frontiers in cell and developmental biology · 2025Review
- Inflammation, coagulation, and cellular injury in heat-induced shock.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Biomarkers of heatstroke-induced organ injury and repair.Experimental physiology · 2022Review
- Heatstroke-induced coagulopathy: Biomarkers, mechanistic insights, and patient management.EClinicalMedicine · 2022Review
- Prognostic value of plasma exosomal levels of histone H3 protein in patients with heat stroke.Experimental and therapeutic medicine · 2021Article
- Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke.Scientific reports · 2021Article
- Sequential Organ Failure Assessment Score for Prediction of Mortality of Patients With Rhabdomyolysis Following Exertional Heatstroke: A Longitudinal Cohort Study in Southern China.Frontiers in medicine · 2021Article
- Expression of heme oxygenase-1 in type II pneumocytes protects against heatstroke-induced lung damage.Cell stress & chaperones · 2021Article
- Dogs Don't Die Just in Hot Cars-Exertional Heat-Related Illness (Heatstroke) Is a Greater Threat to UK Dogs.Animals : an open access journal from MDPI · 2020Article
- Incidence and risk factors for heat-related illness (heatstroke) in UK dogs under primary veterinary care in 2016.Scientific reports · 2020Article
- Plasma procalcitonin concentrations predict organ dysfunction and outcome in dogs with sepsis.BMC veterinary research · 2018Article
- Pathophysiology of heatstroke in dogs - revisited.Temperature (Austin, Tex.) · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heatstroke is associated with systemic inflammatory response syndrome, leading to multiple organ dysfunction and death. Currently, there is no specific treatment decreasing hyperthermia-induced inflammatory/hemostatic derangements. Emerging studies indicate that histones leaking from damaged cells into the extracellular space are toxic, pro-inflammatory, and pro-thrombotic. We therefore hypothesize that serum histones (sHs) are elevated during heatstroke and are associated with the severity of the disease. Sixteen dogs with heatstroke and seven healthy controls were included in the study. Median serum histones (sHs) upon admission in dogs with heatstroke were significantly higher (P = 0.043) compared to that in seven controls (13.2 vs. 7.3 ng/mL, respectively). sHs level was significantly higher among non-survivors and among dogs with severe hemostatic derangement (P = 0.049, median 21.4 ng/mL vs. median 8.16 ng/mL and P = 0.038, 19.0 vs. 7.0 ng/mL, respectively). There were significant positive correlation between sHs and urea (r = 0.8, P = 0.02); total CO2 (r = 0.661, P = 0.05); CK (r = 0.678, P = 0.04); and prothrombin time (PT) 12 h post presentation (r = 0.888, P = 0.04). The significant positive correlation between sHs and other heatstroke severity biomarkers, and significant increase among severely affected dogs, implies its role in inflammation/oxidation/coagulation during heatstroke. sHs, unlike other prognostic and severity biomarkers in heatstroke, can be pharmacologically manipulated, offering a potential therapeutic target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.