Evidence map›Paper›PMID 28643237›Full record

ArticlePharmaceutical research2017

Small Airway Absorption and Microdosimetry of Inhaled Corticosteroid Particles after Deposition.

P Worth Longest, Michael Hindle

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

P Worth LongestDepartment of Mechanical and Nuclear Engineering, Virginia Commonwealth University, 401 West Main Street, Virginia, 23284-3015, USA. pwlongest@vcu.edu.
Michael HindleDepartment of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA.
Virginia Commonwealth University · US

Funding

Predictive Lung Deposition Models for Safety and Efficacy of Orally Inhaled DrugU01FD004570 · FDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI LONGEST, P. WORTH · 2012 to 2014
$347k
FDA HHS U01 FD004570U.S. Food and Drug Administration U01FD004570
6 · The paper itself

Abstract

purposeTo predict the cellular-level epithelial absorbed dose from deposited inhaled corticosteroid (ICS) particles in a model of an expanding and contracting small airway segment for different particle forms.

methodsA computational fluid dynamics (CFD)-based model of drug dissolution, absorption and clearance occurring in the surface liquid of a representative small airway generation (G13) was developed and used to evaluate epithelial dose for the same deposited drug mass of conventional microparticles, nanoaggregates and a true nanoaerosol. The ICS medications considered were budesonide (BD) and fluticasone propionate (FP). Within G13, total epithelial absorption efficiency (AE) and dose uniformity (microdosimetry) were evaluated.

resultsConventional microparticles resulted in very poor AE of FP (0.37%) and highly nonuniform epithelial absorption, such that <5% of cells received drug. Nanoaggregates improved AE of FP by a factor of 57-fold and improved dose delivery to reach approximately 40% of epithelial cells. True nanoaerosol resulted in near 100% AE for both drugs and more uniform drug delivery to all cells.

conclusionsCurrent ICS therapies are absorbed by respiratory epithelial cells in a highly nonuniform manner that may partially explain poor clinical performance in the small airways. Both nanoaggregates and nanoaerosols can significantly improve ICS absorption efficiency and uniformity.

Indexed as

Administration, InhalationAdrenal Cortex HormonesAerosolsAnti-Asthmatic AgentsAsthmaBiological TransportBronchodilator AgentsBudesonideComputational BiologyDrug Delivery SystemsDrug LiberationFluticasoneHumansMolecular Dynamics SimulationNanoparticlesRespiratory TherapyAdrenal Cortex HormonesAerosolsAnti-Asthmatic AgentsBronchodilator AgentsBudesonideFluticasoneAsthmaComputational fluid dynamicsNanoaerosolNanoaggregatePharmaceutical aerosols

Identifiers

PMID28643237
PMCPMC5693636
OpenAlexW2646649866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.