Evidence map›Paper›PMID 28643198›Full record

ArticleApoptosis : an international journal on programmed cell death2017

Urokinase plasminogen activator protects cardiac myocytes from oxidative damage and apoptosis via hOGG1 induction.

Philipp J Hohensinner, Nikol Takacs, Christoph Kaun, Barbara Thaler, Konstantin A Krychtiuk, Stefan Pfaffenberger, Arezu Aliabadi, Andreas Zuckermann, Kurt Huber, Johann Wojta

Open access · hybridAbstract read
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Sodium Alginate Attenuates HMolecular biotechnology · 2026
    Article
  2. Article
  3. Pharmacologic modulation of intracellular NaProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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  12. Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.American journal of physiology. Heart and circulatory physiology · 2018
    Article
  13. Antiviral Immunotoxin AgainstFrontiers in microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Philipp J HohensinnerDepartment of Internal Medicine II, Cardiology, Medical University of Vienna, Währingergürtel 18-20, 1090, Vienna, Austria. philipp.hohensinner@meduniwien.ac.at.
Nikol TakacsDepartment of Internal Medicine II, Cardiology, Medical University of Vienna, Währingergürtel 18-20, 1090, Vienna, Austria.
Christoph KaunDepartment of Internal Medicine II, Cardiology, Medical University of Vienna, Währingergürtel 18-20, 1090, Vienna, Austria.
Barbara ThalerDepartment of Internal Medicine II, Cardiology, Medical University of Vienna, Währingergürtel 18-20, 1090, Vienna, Austria.
Konstantin A KrychtiukDepartment of Internal Medicine II, Cardiology, Medical University of Vienna, Währingergürtel 18-20, 1090, Vienna, Austria.
Stefan PfaffenbergerDepartment of Internal Medicine II, Cardiology, Medical University of Vienna, Währingergürtel 18-20, 1090, Vienna, Austria.
Arezu AliabadiDepartment of Surgery, Medical University of Vienna, Vienna, Austria.
Andreas ZuckermannDepartment of Surgery, Medical University of Vienna, Vienna, Austria.
Kurt Huber3rd Medical Department, Wilhelminenhospital, Vienna, Austria.
Johann WojtaDepartment of Internal Medicine II, Cardiology, Medical University of Vienna, Währingergürtel 18-20, 1090, Vienna, Austria.
Medical University of Vienna · ATWilhelminen Hospital · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of uPA in tissue remodeling and cell migration is already well established. In addition, uPA was reported to stabilize p53, a key cell cycle control, DNA repair and apoptosis initiation protein. We aimed to determine the role of uPA-uPAR signaling towards cell survival or apoptosis in human adult cardiac myocytes (HACM). HACM were stimulated with uPA and DNA damage was inflicted by incubating cells with 200 µM H

Indexed as

ApoptosisCell MovementDNA DamageDNA GlycosylasesGene Expression RegulationHumansHydrogen PeroxideMyocytes, CardiacOxidative StressReceptors, Urokinase Plasminogen ActivatorSignal TransductionTumor Suppressor Protein p53Urokinase-Type Plasminogen ActivatorDNA GlycosylasesHydrogen Peroxideoxoguanine glycosylase 1, humanReceptors, Urokinase Plasminogen ActivatorTP53 protein, humanTumor Suppressor Protein p53Urokinase-Type Plasminogen ActivatorhOGG1Oxidative DNA damageP53 pathwayUrokinase plasminogen activator

Identifiers

PMID28643198
PMCPMC5486847
OpenAlexW2708301743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.