ReviewDer Unfallchirurg2017
[Local antibiotic therapy].
Review in Der Unfallchirurg, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Impact of surface structuring on antibiotic elution from bone cement in two-stage revision for periprosthetic joint infection.BMC musculoskeletal disorders · 2026Article
- Radiographic parameters and mechanical complications of articulating vs. non-articulating hip spacers.Archives of orthopaedic and trauma surgery · 2026Article
- Unilateral biportal endoscopic debridement with antibiotic-loaded cement beads implantation for lumbar spinal infection: a preliminary report on feasibility and early clinical outcomes.Frontiers in cellular and infection microbiology · 2026Article
- The effect of pulsatile lavage on antibiotic elution from bone cements in two-stage revision for periprosthetic joint infection.Journal of orthopaedic surgery and research · 2025Article
- Biomechanical analysis of additional vancomycin in articulating knee spacers: determining the threshold for structural failure.Archives of orthopaedic and trauma surgery · 2025Article
- Clinically applicable antibiotic modification of ready-to-use calcium phosphate cement pastes.Journal of orthopaedic surgery and research · 2025Article
- In Vivo Antibiotic Elution and Inflammatory Response During Two-Stage Total Knee Arthroplasty Revision: A Microdialysis Pilot Study.Antibiotics (Basel, Switzerland) · 2025Article
- Antibiotic Elution from Cement Spacers and Its Influencing Factors.Antibiotics (Basel, Switzerland) · 2025Review
- Enhancing orthopedic outcomes: A comparative analysis of gentamicin sulphate and nanosilver in bone cement.Heliyon · 2024Article
- Cemented Calcar-Guided Short-Stem Prostheses in Geriatric Patients: Short-Term Results from a Prospective Observational Study.Antibiotics (Basel, Switzerland) · 2024Article
- Evidence for cemented TKA and THA based on a comparison of international register data.Orthopadie (Heidelberg, Germany) · 2024Review
- Effectiveness of combined local therapy with antibiotics and fibrin vs. vacuum-assisted wound therapy in soft tissue infections: a retrospective study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- [Preliminary application of antibiotic bone cement directly inducing skin regeneration technology in repairing of wound in lateral toe flap donor area].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Article
- [Register data on cemented arthroplasty : A proof for cementless fixation?]Orthopadie (Heidelberg, Germany) · 2024Review
- Impact of Anti-Mycotic Drugs on the Osteogenic Response of Bone Marrow Mesenchymal Stem Cells In Vitro.Antibiotics (Basel, Switzerland) · 2024Article
- [Chemical and physical properties of PMMA bone cements].Orthopadie (Heidelberg, Germany) · 2023Review
- [Processing properties and viscosities of PMMA bone cements].Orthopadie (Heidelberg, Germany) · 2023Review
- [Bone cement as a local antibiotic carrier].Orthopadie (Heidelberg, Germany) · 2023Review
- Vancomycin Loaded Amino-Functionalized MCM-48 Mesoporous Silica Nanoparticles as a Promising Drug Carrier in Bone Substitutes for Bacterial Infection Management.Applied biochemistry and biotechnology · 2023Article
- Enhanced antibiotic release from bone cement spacers utilizing dual antibiotic loading with elevated vancomycin concentrations in two-stage revision for periprosthetic joint infection.International orthopaedics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of superficial wound infections with local antibiotics is considered to be problematic as it is accompanied by an increased risk of resistance development and ineffectiveness in deeper regions. On the contrary, the local application of antibiotics is useful in arthroplasty and necessary if implants are utilized. The reason for this is the prevention of a rapid biofilm formation on foreign implants and a resulting infection may remain undiscovered until it becomes chronic. Apart from exogenous material, necrotic tissue (e. g. bone sequestra) provides suitable retreat areas for pathogens in the body. Because of the characteristics of bone and joint infections and an exceptional infection recurrence rate, a combined approach is required. Systemic antibiotic prophylaxis is able to reduce the number of pathogens acquired by perioperative contamination or hematogenic spread from another focus of infection; however, systemically applied antibiotics often fail to form an effective colonization barrier around the implant because their ability to penetrate the bone is relatively low. On the other hand, the high concentration of locally released antibiotics leads to an effective protection of the implant from bacteria in situ. Thus, for the treatment of implant-associated infections, systemic and local application of anti-infective agents is a reliable adjuvant measure that improves the therapeutic success. Polymethylmethacrylate (PMMA) bone cement is the most commonly used local drug carrier. Based on clinical and microbiological results, microbiologists and infectious disease experts together with the surgeon and pharmacist determine which anti-infective agents are indicated for systemic and local, PMMA cement-related application. Because there is no evident concept for the local application, unlike the recommendation for systemic use of anti-infective agents, this review article describes which aspects should be taken into account.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.