ArticleEcoHealth2017
Sylvatic Plague Vaccine Partially Protects Prairie Dogs (Cynomys spp.) in Field Trials.
Article in EcoHealth, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Trial
- Effects of fipronil bait pellets on two cricetid species: Potential implications for plague mitigation and wildlife conservation.International journal for parasitology. Parasites and wildlife · 2026Article
- From protection to amplification: Imperfect chytridiomycosis prophylaxis increases infections in wild amphibians.bioRxiv : the preprint server for biology · 2026Article
- Article
- Oral delivery of bovine tuberculosis vaccine to free-ranging white-tailed deer.Frontiers in veterinary science · 2025Article
- Prairie dog responses to vector control and vaccination during an initialInternational journal for parasitology. Parasites and wildlife · 2024Article
- Plague mitigation for prairie dog and black-footed ferret conservation: Degree and duration of flea control with 0.005% fipronil grain bait.Current research in parasitology & vector-borne diseases · 2023Article
- Exploring and Mitigating Plague for One Health Purposes.Current tropical medicine reports · 2022Article
- Oral Sylvatic Plague Vaccine Does Not Adequately Protect Prairie Dogs (Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2021Article
- Plague vaccines: new developments in an ongoing search.Applied microbiology and biotechnology · 2021Review
- Characterizing patterns of genomic variation in the threatened Utah prairie dog: Implications for conservation and management.Evolutionary applications · 2021Article
- Applied ecoimmunology: using immunological tools to improve conservation efforts in a changing world.Conservation physiology · 2021Article
- Review
- An invasive disease, sylvatic plague, increases fragmentation of black-tailed prairie dog (Cynomys ludovicianus) colonies.PloS one · 2020Article
- Mucosal vaccines and technology.Clinical and experimental immunology · 2019Review
- Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus).Scientific reports · 2019Article
- Prairie Dogs, Persistent Plague, Flocking Fleas, and Pernicious Positive Feedback.Frontiers in veterinary science · 2019Article
- Plague vaccine: recent progress and prospects.NPJ vaccines · 2019Review
- Impact of Sylvatic Plague Vaccine on Non-target Small Rodents in Grassland Ecosystems.EcoHealth · 2018Article
- Local factors associated with on-host flea distributions on prairie dog colonies.Ecology and evolution · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sylvatic plague, caused by Yersinia pestis, frequently afflicts prairie dogs (Cynomys spp.), causing population declines and local extirpations. We tested the effectiveness of bait-delivered sylvatic plague vaccine (SPV) in prairie dog colonies on 29 paired placebo and treatment plots (1-59 ha in size; average 16.9 ha) in 7 western states from 2013 to 2015. We compared relative abundance (using catch per unit effort (CPUE) as an index) and apparent survival of prairie dogs on 26 of the 29 paired plots, 12 with confirmed or suspected plague (Y. pestis positive carcasses or fleas). Even though plague mortality occurred in prairie dogs on vaccine plots, SPV treatment had an overall positive effect on CPUE in all three years, regardless of plague status. Odds of capturing a unique animal were 1.10 (95% confidence interval [C.I.] 1.02-1.19) times higher per trap day on vaccine-treated plots than placebo plots in 2013, 1.47 (95% C.I. 1.41-1.52) times higher in 2014 and 1.19 (95% C.I. 1.13-1.25) times higher in 2015. On pairs where plague occurred, odds of apparent survival were 1.76 (95% Bayesian credible interval [B.C.I.] 1.28-2.43) times higher on vaccine plots than placebo plots for adults and 2.41 (95% B.C.I. 1.72-3.38) times higher for juveniles. Our results provide evidence that consumption of vaccine-laden baits can protect prairie dogs against plague; however, further evaluation and refinement are needed to optimize SPV use as a management tool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.