ArticleNaunyn-Schmiedeberg's archives of pharmacology2017
Gallic and ellagic acids: two natural immunomodulator compounds solve infection of macrophages by Leishmania major.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Ellagic acid in poultry nutrition: emerging roles in gut health, immunity, and sustainable production.Poultry science · 2026Review
- Dietary Ellagic Acid Protects and Ameliorates Copper Sulfate-Induced Toxicity in Common Carp (Veterinary sciences · 2026Article
- Octyl Gallate Exhibits Trypanocidal Activity Through Trypanothione Reductase Inhibition and Immunomodulation In Vitro.Biomedicines · 2026Article
- Limonene and carvacrol combined with drugs that inhibit ergosterol synthesis are potent against Leishmania major.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- A Comprehensive Review on Immunoregulatory Effects of Phytochemicals.Current drug discovery technologies · 2025Review
- VBNC Cronobacter sakazakii survives in macrophages by resisting oxidative stress and evading recognition by macrophages.BMC microbiology · 2024Article
- Immunotherapeutic Strategies as Potential Treatment Options for Cutaneous Leishmaniasis.Vaccines · 2024Review
- Article
- Anti-Leishmania major activity of Calotropis procera extract by increasing ROS production and upregulating TNF-α, IFN-γ and iNOS mRNA expression under in vitro conditions.Tropical medicine and health · 2024Article
- Leishmanicidal and immunomodulatory activity ofHeliyon · 2024Article
- Enhanced activity of Ellagic acid in lipid nanoparticles (EA-liposomes) againstSaudi journal of biological sciences · 2023Article
- Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root ofMolecules (Basel, Switzerland) · 2023Article
- Dietary Strategies for Relieving Stress in Pet Dogs and Cats.Antioxidants (Basel, Switzerland) · 2023Review
- In vitro and in vivo therapeutic antileishmanial potential of ellagic acid against Leishmania donovani in murine model.Medical microbiology and immunology · 2023Article
- Isopropyl Gallate, a Gallic Acid Derivative: In Silico and In Vitro Investigation of Its Effects onPharmaceutics · 2022Article
- Immunomodulatory Activity of Punicalagin, Punicalin, and Ellagic Acid Differs from the Effect of Pomegranate Peel Extract.Molecules (Basel, Switzerland) · 2022Article
- Biflavones fromPathogens (Basel, Switzerland) · 2021Article
- Natural Products That Target the Arginase inMicroorganisms · 2021Review
- Gallic and Ellagic Acids Are Promising Adjuvants to Conventional Amphotericin B for the Treatment of Cutaneous Leishmaniasis.Antimicrobial agents and chemotherapy · 2020Article
- Impact of Gallic Acid on Gut Health: Focus on the Gut Microbiome, Immune Response, and Mechanisms of Action.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leishmaniasis is a complex of parasitic protozoan diseases caused by more than 20 different species of parasites from Leishmania genus. Conventional treatments are high costly, and promote a sort of side effects. Besides, protozoan resistance to treatments has been reported. Natural products have been investigated as a source of new therapeutic alternatives, not only acting directly against the parasite but also being able to synergistically act on the host immune system in order to control parasitemia. Gallic acid (GA) and ellagic acid (EA) are plant-derived phenolic compounds which are able to induce antiinflammatory, gastroprotective, and anticarcinogenic activities. Therefore, the antileishmania, cytotoxic, and immunomodulatory activities of GA and EA were evaluated in this study. Both GA and EA were able to inhibit the growth of Leishmania major promastigotes (effective concentration (EC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.