Evidence map›Paper›PMID 28643048›Full record

Observational studyOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Association of gastrointestinal events with quality of life and treatment satisfaction in osteoporosis patients: results from the Medication Use Patterns, Treatment Satisfaction, and Inadequate Control of Osteoporosis Study (MUSIC OS).

A Modi, S Sen, J D Adachi, S Adami, B Cortet, A L Cooper, P Geusens, D Mellström, J P Weaver, J P van den Bergh and 2 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

A ModiCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA. ankita.modi@merck.com.
S SenCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA.
J D AdachiSt Joseph's Healthcare and McMaster University, Hamilton, ON, Canada.
S AdamiDepartment of Medicine, University of Verona, Verona, Italy.
B CortetDepartment of Rheumatology, University Hospital of Lille, Lille Cedex, France.
A L CooperBridge Medical Center, Crawley, West Sussex, UK.
P GeusensDepartment of Rheumatology, Maastricht University Medical Center, Maastricht, The Netherlands.
D MellströmDepartment of Internal Medicine and Geriatrics, Gothenburg University, Gothenburg, Sweden.
J P WeaverCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA.
J P van den BerghDepartment of Rheumatology, Maastricht University Medical Center, Maastricht, The Netherlands.
P A KeownSyreon Corporation, Vancouver, Canada.
S SajjanCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to assess the association of GI events with HRQoL and treatment satisfaction. The effect of baseline GI events persisted through 1 year of follow-up, as indicated by lower EQ-5D, OPAQ-SV, and treatment satisfaction scores among patients with vs without baseline GI events. The presence of GI events is an independent predictor of decreased HRQoL and treatment satisfaction in patients being treated for osteoporosis.

introductionThe goal of this study was to assess the association of gastrointestinal (GI) events with health-related quality of life (HRQoL) and treatment satisfaction in patients being treated for osteoporosis.

methodsMUSIC OS was a multinational, prospective, observational study examining the impact of GI events on osteoporosis management in postmenopausal women. In this analysis, HRQoL and treatment satisfaction were assessed at baseline, 6, and 12 months and compared between patients with and without GI events. Covariate-adjusted scores were calculated using multivariate least-squares regression analysis, and differences between the mean scores of patients with and without baseline and post-baseline GI events were determined.

resultsAmong the 2959 patients in the analysis, unadjusted scores at each time point were lower (i.e., worse) for patients with GI events than patients without GI events. In adjusted analyses, the effect of baseline GI events persisted through 1 year of follow-up, as indicated by lower EQ-5D and OPAQ-SV scores at 12 months among patients with vs without baseline GI events (-0.04 for the EQ-5D utility score, -5.07 for the EQ-5D visual analog scale, -3.35 for OPAQ physical function, -4.60 for OPAQ emotional status, and -8.50 for OPAQ back pain; P ≤ 0.001 for all values). Decrements in month 12 treatment satisfaction scores were -6.46 for patients with baseline GI events and -7.88 for patients with post-baseline GI events.

conclusionsThe presence of GI events is an independent predictor of decreased HRQoL and treatment satisfaction in patients being treated for osteoporosis.

Indexed as

Quality of LifeAgedBone Density Conservation AgentsCanadaDrug UtilizationEuropeFemaleFollow-Up StudiesGastrointestinal DiseasesHumansMiddle AgedOsteoporosis, PostmenopausalPatient SatisfactionProspective StudiesPsychometricsBone Density Conservation AgentsGastrointestinal diseasesOsteoporosisPatient satisfactionPostmenopausalQuality of life

Identifiers

PMID28643048
PMCPMC5624972

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.