ArticleThe international journal of cardiovascular imaging2017
Impact of left ventricular longitudinal functional mechanics on the progression of diastolic function in diabetes mellitus.
Article in The international journal of cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 31 citations in OpenAlex.
- Strain imaging in heart failure: from early detection to prognostic assessment.ESC heart failure · 2026Review
- Combined with the insulin resistance index in assessing subclinical systolic function in newly diagnosed type 2 diabetes mellitus: an analysis based on automated functional imaging echocardiography.BMC endocrine disorders · 2025Article
- Evolving role of echocardiography across the heart failure spectrum: from prevention to advanced management.Heart failure reviews · 2025Review
- Subclinical Myocardial Dysfunction in Type 2 Diabetes Mellitus: Insights from Left Ventricular Diastolic Function and Global Longitudinal Strain Assessment.Medical sciences (Basel, Switzerland) · 2025Article
- The Contribution of Echocardiography to the Diagnosis and Prognosis Stratification of Diabetic Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2025Review
- The protective effect of sodium-glucose cotransporter-2 inhibitor on left ventricular global longitudinal strain in patients with type 2 diabetes mellitus according to disease duration.Scientific reports · 2025Article
- Analysis of Factors Related to Early Left Ventricular Dysfunction in Hypertensive Patients with Preserved Ejection Fraction Using Speckle Tracking Echocardiography: A Cross-Sectional Study in Vietnam.Diagnostics (Basel, Switzerland) · 2025Article
- Speckle-Tracking Analysis of the Right and Left Heart after Peak Exercise in Healthy Subjects with Type 1 Diabetes: An Explorative Analysis of the AppEx Trial.Journal of cardiovascular development and disease · 2023Article
- Impact of glycemic control on biventricular function in patients with type 2 diabetes mellitus: a cardiac magnetic resonance tissue tracking study.Insights into imaging · 2023Article
- Association between diabetic nephropathy and left ventricular longitudinal myocardial function in type 1 diabetes mellitus patients with preserved ejection fraction.The international journal of cardiovascular imaging · 2022Article
- Role of strain echocardiography in patients with hypertension.Clinical hypertension · 2022Review
- Diabetic cardiomyopathy: Clinical phenotype and practice.Frontiers in endocrinology · 2022Review
- Association of left ventricular longitudinal myocardial function with subclinical right ventricular dysfunction in type 2 diabetes mellitus.Cardiovascular diabetology · 2021Article
- Key factors of diastolic dysfunction and abnormal left ventricular relaxation in diabetic rats.Journal of medical ultrasonics (2001) · 2020Article
- Impact of diabetes mellitus on left ventricular longitudinal function of patients with non-ischemic dilated cardiomyopathy.Cardiovascular diabetology · 2020Article
- Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model.Acta diabetologica · 2020Article
- Positive effect of dapagliflozin on left ventricular longitudinal function for type 2 diabetic mellitus patients with chronic heart failure.Cardiovascular diabetology · 2020Article
- Utility of strain imaging in conjunction with heart failure stage classification for heart failure patient management.Journal of echocardiography · 2019Review
- The relationships between the pulsatile flow form of ocular microcirculation by laser speckle flowgraphy and the left ventricular end-diastolic pressure and mass.The international journal of cardiovascular imaging · 2018Article
- Early detection of left ventricular diastolic dysfunction using conventional and speckle tracking echocardiography in a large animal model of metabolic dysfunction.The international journal of cardiovascular imaging · 2018Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Left ventricular (LV) diastolic dysfunction and longitudinal systolic dysfunction were identified in patients with diabetes mellitus (DM). This study's aim was to investigate the impact of LV longitudinal systolic function on LV diastolic function in DM patients with preserved LV ejection fraction (LVEF). We studied 177 DM patients with preserved LVEF (all ≥50%), and 82 age-, gender- and LVEF-matched healthy volunteers as control. Global longitudinal strain (GLS) was defined as the average peak strain of 18 segments from standard apical views, GLS <18% as subclinical LV systolic dysfunction (LVSD), and LV dispersion as the standard deviation of time-to-peak strain from the same views. For DM patients with LVSD (n = 74), E/A and E' were lower, and E/E' and isovolumic relaxation time (IVRT) were greater than for DM patients without LVSD (n = 103) and normal controls (n = 82). Moreover, these parameters were lower for DM patients without LVSD than for normal controls. Multivariate analysis revealed that GLS was a strong determinative factor for E' and E/E' (β = 0.30, p < 0.001 and β = -0.25, p < 0.001, respectively), as was LV dispersion for E-wave deceleration time and IVRT (β = 0.21, p = 0.002 and β = 0.30, p < 0.001, respectively) independently of age. For normal subjects, however, only age was associated with all LV diastolic parameters. In conclusions, in contrast to age-related LV diastolic dysfunction in normal subjects, in DM patients with preserved LVEF, LV diastolic function was associated with LV longitudinal systolic function and LV dispersion independently of age. Our findings have obvious clinical implications for the management of DM patients.
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