Evidence map›Paper›PMID 28642875›Full record

ArticleBioMed research international2017

Rapid Elimination of Blood Alcohol Using Erythrocytes: Mathematical Modeling and In Vitro Study.

Yuliya G Alexandrovich, Elena A Kosenko, Elena I Sinauridze, Sergey I Obydennyi, Igor I Kireev, Fazoil I Ataullakhanov, Yuriy G Kaminsky

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yuliya G AlexandrovichLaboratory of Biophysics and Physiology of the Cell, Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Kosygin Street 4, Moscow 119334, Russia.
Elena A KosenkoLaboratory of Modeling and Bioinformatics, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya Street 3, Pyshchino, Moscow Region 142290, Russia.ORCID 0000-0002-3293-652X
Elena I SinauridzeLaboratory of Biophysics and Physiology of the Cell, Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Kosygin Street 4, Moscow 119334, Russia.ORCID 0000-0002-5948-3444
Sergey I ObydennyiLaboratory of Biophysics and Physiology of the Cell, Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Kosygin Street 4, Moscow 119334, Russia.ORCID 0000-0002-2930-8768
Igor I KireevDepartment of Electron Microscopy, Moscow State University, Belozersky Institute of Physico-Chemical Biology, Leninskie Gory 1, Building 40, Moscow 119992, Russia.
Fazoil I AtaullakhanovLaboratory of Biophysics and Physiology of the Cell, Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Kosygin Street 4, Moscow 119334, Russia.ORCID 0000-0002-6668-0948
Yuriy G KaminskyLaboratory of Modeling and Bioinformatics, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya Street 3, Pyshchino, Moscow Region 142290, Russia.
Institute of Theoretical and Experimental Biophysics · RULomonosov Moscow State University · RUMinistry of Health of the Russian Federation · RUCenter for Theoretical Problems of Physicochemical Pharmacology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erythrocytes (RBCs) loaded with alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALD) can metabolize plasma ethanol and acetaldehyde but with low efficiency. We investigated the rate-limiting factors in ethanol oxidation by these enzymes loaded into RBCs. Mathematical modeling and in vitro experiments on human RBCs loaded simultaneously with ADH and ALD (by hypoosmotic dialysis) were performed. The simulation showed that the rate of nicotinamide-adenine dinucleotide (NAD

Indexed as

Models, TheoreticalAcetaldehydeAlcohol DehydrogenaseAlcoholic IntoxicationAldehyde DehydrogenaseErythrocytesEthanolHumansMetabolic Clearance RateOxidation-ReductionAcetaldehydeAlcohol DehydrogenaseAldehyde DehydrogenaseEthanol

Identifiers

PMID28642875
PMCPMC5470050
OpenAlexW2618844407

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.