ArticleInternational journal of genomics2017
An Exploration of Gene-Gene Interactions and Their Effects on Hypertension.
Article in International journal of genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Associating complex traits with genetic variants: polygenic risk scores, pleiotropy and endophenotypes.Genetica · 2022Article
- Identifying the degree of genetic interactions using Restricted Boltzmann Machine-A study on colorectal cancer.IET systems biology · 2021Article
- A comparison of methods for interpreting random forest models of genetic association in the presence of non-additive interactions.BioData mining · 2021Article
- G2G: A web-server for the prediction of human synthetic lethal interactions.Computational and structural biotechnology journal · 2020Article
- Familial aggregation and heritability of hypertension in Han population in Shanghai China: a case-control study.Clinical hypertension · 2019Article
- Full genetic analysis for genome-wide association study of Fangji: a powerful approach for effectively dissecting the molecular architecture of personalized traditional Chinese medicine.Acta pharmacologica Sinica · 2018Review
- Interaction between polymorphisms in cell-cycle genes and environmental factors in regulating cholinesterase activity in people with exposure to omethoate.Royal Society open science · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20-60%. So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies. Therefore, the current study explored gene-gene interactions that have the potential to partially fill in the missing heritability. A two-stage discovery-confirmatory analysis was carried out in the Framingham Heart Study cohorts. The first stage was an exhaustive pairwise search performed in 2320 early-onset hypertensive cases with matched normotensive controls from the offspring cohort. Then, identified gene-gene interactions were assessed in an independent set of 694 subjects from the original cohort. Four unique gene-gene interactions were found to be related to hypertension. Three detected genes were recognized by previous studies, and the other 5 loci/genes (
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Registered trials
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