Evidence map›Paper›PMID 28642749›Full record

ArticleFrontiers in microbiology2017

RNA-Seq Reveals Enhanced Sugar Metabolism in

Jinzhi He, Dongyeop Kim, Xuedong Zhou, Sang-Joon Ahn, Robert A Burne, Vincent P Richards, Hyun Koo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.

  1. Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022
    Pooled it
  2. Review
  3. Article
  4. AJournal of bacteriology · 2026
    Review
  5. Review
  6. Frontiers in microbiology · 2026
    Article
  7. Effect ofJournal of dental research · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. The Oral Microbiome: A Key Determinant of Oral Health.Advances in experimental medicine and biology · 2025
    Review
  14. Interactions between non-Journal of oral microbiology · 2025
    Article
  15. Article
  16. Arginine inhibits cross-kingdom interactions and synergistic cariogenicity betweenFrontiers in cellular and infection microbiology · 2025
    Article
  17. Microbiome variability and role ofJournal of oral microbiology · 2025
    Article
  18. Journal of oral microbiology · 2025
    Article
  19. Microorganisms · 2024
    Review
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jinzhi HeState Key Laboratory of Oral Diseases, Department of Endodontics, West China Hospital of Stomatology, Sichuan UniversityChengdu, China.
Dongyeop KimBiofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, PhiladelphiaPA, United States.
Xuedong ZhouState Key Laboratory of Oral Diseases, Department of Endodontics, West China Hospital of Stomatology, Sichuan UniversityChengdu, China.
Sang-Joon AhnDepartment of Oral Biology, College of Dentistry, University of Florida, GainesvilleFL, United States.
Robert A BurneDepartment of Oral Biology, College of Dentistry, University of Florida, GainesvilleFL, United States.
Vincent P RichardsDepartment of Biological Sciences, Clemson University, ClemsonSC, United States.
Hyun KooBiofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, PhiladelphiaPA, United States.
State Key Laboratory of Oral DiseasesUniversity of Florida · USUniversity of Pennsylvania · USClemson University · US

Funding

Evaluation of a Novel Anti-Caries Approach to Modulate Virulence of S. mutansR01DE018023 · NIDCR · UNIVERSITY OF ROCHESTER · PI KOO, HYUN · 2008 to 2019
$3.4M
S. mutans-C. albicans interactions synergize the virulence of cariogenic biofilmsR01DE025220 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI KOO, HYUN · 2015 to 2019
$2.0M
NIDCR NIH HHS R01 DE018023NIDCR NIH HHS R01 DE025220
6 · The paper itself

Abstract

Early childhood caries (ECC), which can lead to rampant tooth-decay that is painful and costly to treat, is one of the most prevalent infectious diseases affecting children worldwide. Previous studies support that interactions between

Indexed as

biofilmsCandida albicansearly childhood cariesRNA-SeqStreptococcus mutanstranscriptome

Identifiers

PMID28642749
PMCPMC5462986
OpenAlexW2622761324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.