Evidence map›Paper›PMID 28642691›Full record

ArticleFrontiers in integrative neuroscience2017

MRI Overestimates Excitotoxic Amygdala Lesion Damage in Rhesus Monkeys.

Benjamin M Basile, Chloe L Karaskiewicz, Emily C Fiuzat, Ludise Malkova, Elisabeth A Murray

Open access · goldAbstract read
In one paragraph

Article in Frontiers in integrative neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. The Orbitofrontal Cortex Underlies Consolidation of Pavlovian Anticipatory Arousal Responses in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  2. Motor System-Dependent Effects of Amygdala and Ventral Striatum Lesions on Explore-Exploit Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Heightened Defensive Responses Following Subtotal Lesions of Macaque Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  7. Amygdala lesions eliminate viewing preferences for faces in rhesus monkeys.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Benjamin M BasileSection on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health (NIH)Bethesda, MD, United States.
Chloe L KaraskiewiczSection on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health (NIH)Bethesda, MD, United States.
Emily C FiuzatSection on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health (NIH)Bethesda, MD, United States.
Ludise MalkovaDepartment of Pharmacology and Physiology, Georgetown University Medical CenterWashington, DC, United States.
Elisabeth A MurraySection on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health (NIH)Bethesda, MD, United States.
National Institute of Mental Health · USGeorgetown University Medical Center · US

Funding

Neural Substrates of Reward Processing and EmotionZIAMH002887 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MURRAY, ELISABETH A · 2009 to 2025
$26.0M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2016 to 2020
$5.9M
Intramural NIH HHS ZIA MH002887NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

Selective, fiber-sparing excitotoxic lesions are a state-of-the-art tool for determining the causal contributions of different brain areas to behavior. For nonhuman primates especially, it is advantageous to keep subjects with high-quality lesions alive and contributing to science for many years. However, this requires the ability to estimate lesion extent accurately. Previous research has shown that

Indexed as

amygdalaexcitotoxicibotenic acidlesionnonhuman primateT2 MRI

Identifiers

PMID28642691
PMCPMC5462941
OpenAlexW2622136636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.