Evidence map›Paper›PMID 28642680›Full record

ArticleFrontiers in neuroscience2017

Weight Bearing Over-ground Stepping in an Exoskeleton with Non-invasive Spinal Cord Neuromodulation after Motor Complete Paraplegia.

Parag Gad, Yury Gerasimenko, Sharon Zdunowski, Amanda Turner, Dimitry Sayenko, Daniel C Lu, V Reggie Edgerton

Registry-linked trialOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06939660 (Spatiotemporal Spinal Cord Stimulation Based on Implantable Brain-machine Interfaces and Exoskeletons for Spinal Cord Injury), which is not on this map. Cited by 100 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 3 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06939660 narecruitingnot on this mapstarted 2025, after this paper: background citation

Spatiotemporal Spinal Cord Stimulation Based on Implantable Brain-machine Interfaces and Exoskeletons for Spinal Cord Injury (BASEGO)

TypeinterventionalSponsorXuanwu Hospital, BeijingRan2025 to 2027Enrolled3ConditionsSpinal Cord Injuries (SCI), Spinal Cord Injury, Chronic, Spinal Cord Injury, Spinal Cord Injury CervicalArmsBCI-SCS-EXS
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 3 syntheses or guidelines pooled it, 168 citations in OpenAlex.

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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Parag GadDepartment of Integrative Biology and Physiology, University of California, Los AngelesLos Angeles, CA, United States.
Yury GerasimenkoDepartment of Integrative Biology and Physiology, University of California, Los AngelesLos Angeles, CA, United States.
Sharon ZdunowskiDepartment of Integrative Biology and Physiology, University of California, Los AngelesLos Angeles, CA, United States.
Amanda TurnerDepartment of Integrative Biology and Physiology, University of California, Los AngelesLos Angeles, CA, United States.
Dimitry SayenkoDepartment of Integrative Biology and Physiology, University of California, Los AngelesLos Angeles, CA, United States.
Daniel C LuDepartment of Neurosurgery, University of California, Los AngelesLos Angeles, CA, United States.
V Reggie EdgertonDepartment of Integrative Biology and Physiology, University of California, Los AngelesLos Angeles, CA, United States.
University of California, Los Angeles · USPavlov Institute of Physiology of the Russian Academy of Sciences · RUUniversitat Autònoma de Barcelona · ES

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NCATS NIH HHS UL1 TR000124
6 · The paper itself

Abstract

We asked whether coordinated voluntary movement of the lower limbs could be regained in an individual having been completely paralyzed (>4 year) and completely absent of vision (>15 year) using two novel strategies-transcutaneous electrical spinal cord stimulation at selected sites over the spine as well as pharmacological neuromodulation by buspirone. We also asked whether these neuromodulatory strategies could facilitate stepping assisted by an exoskeleton (EKSO, EKSO Bionics, CA) that is designed so that the subject can voluntarily complement the work being performed by the exoskeleton. We found that spinal cord stimulation and drug enhanced the level of effort that the subject could generate while stepping in the exoskeleton. In addition, stimulation improved the coordination patterns of the lower limb muscles resulting in a more continuous, smooth stepping motion in the exoskeleton along with changes in autonomic functions including cardiovascular and thermoregulation. Based on these data from this case study it appears that there is considerable potential for positive synergistic effects after complete paralysis by combining the over-ground step training in an exoskeleton, combined with transcutaneous electrical spinal cord stimulation either without or with pharmacological modulation.

Indexed as

exoskeletonlocomotion rehabilitationneural prostheses for locomotionnon-invasive neuromodulationspinal cord injuryspinal cord stimulation

Identifiers

PMID28642680
PMCPMC5462970
OpenAlexW2622806574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.