ArticleScientific reports2017
Ultrasound-mediated piezoelectric differentiation of neuron-like PC12 cells on PVDF membranes.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 192 citations in OpenAlex.
- Magnetoelectric microrobots for spinal cord injury regeneration.Nature materials · 2026Article
- Three-Dimensional Magnetoelectric Nanocomposite GelMA Hydrogels for Wireless Electrical Stimulation of Cardiac Cells.ACS applied materials & interfaces · 2026Article
- A Sustainable Alternative to PVDF for Neural Tissue Engineering via Piezoelectric PHBV and Cellulose Acetate Fibers.ACS biomaterials science & engineering · 2026Article
- Electrical Microenvironment Reconstruction and the Application of Biomaterials in Spinal Cord Injury.Journal of functional biomaterials · 2026Review
- Electric field stimulation-responsive hydrogels for bone regeneration: from mechanisms to applications.Bone research · 2026Review
- Wireless Acousto-Piezoelectric Conduit with Aligned Nanofibers for Neural Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Design and Manufacturing of Piezoelectric Biomaterials for Bioelectronics and Biomedical Applications.Chemical reviews · 2025Review
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Ultrasound-activated piezoelectric nanostickers for neural stem cell therapy of traumatic brain injury.Nature materials · 2025Article
- Multifunctional magneto-electric and exosome-loaded hydrogel enhances neuronal differentiation and immunoregulation through remote non-invasive electrical stimulation for neurological recovery after spinal cord injury.Bioactive materials · 2025Article
- Biodegradable Piezoelectric Micro- and Nanomaterials for Regenerative Medicine, Targeted Therapy, and Microrobotics.Small science · 2025Review
- Ultrasound-Responsive Polymeric Piezoelectric Nanoparticles for Remote Activation and Neuronal Differentiation of Human Neural Stem Cells.Small science · 2025Article
- Biomaterials for neuroengineering: applications and challenges.Regenerative biomaterials · 2025Review
- Engineering 3D Scaffold-Free Nanoparticle-Laden Stem Cell Constructs for Piezoelectric Enhancement of Human Neural Tissue Formation and Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Biomimetic electrospun PVDF/self-assembling peptide piezoelectric scaffolds for neural stem cell transplantation in neural tissue engineering.RSC advances · 2024Article
- Recent Advancements in Bone Tissue Engineering: Integrating Smart Scaffold Technologies and Bio-Responsive Systems for Enhanced Regeneration.International journal of molecular sciences · 2024Review
- Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review.Materials today. Bio · 2024Review
- An electromechanical stimulation regulating model with flexoelectric effect of piezoelectric laminated micro-beam for cell bionic culture.Scientific reports · 2024Article
- Piezoelectric Nanomaterial-Mediated Physical Signals Regulate Cell Differentiation for Regenerative Medicine.Small science · 2024Article
- Physical Stimulation Methods Developed for In Vitro Neuronal Differentiation Studies of PC12 Cells: A Comprehensive Review.International journal of molecular sciences · 2024Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
Abstract
Electrical and/or electromechanical stimulation has been shown to play a significant role in regenerating various functionalities in soft tissues, such as tendons, muscles, and nerves. In this work, we investigate the piezoelectric polymer polyvinylidene fluoride (PVDF) as a potential substrate for wireless neuronal differentiation. Piezoelectric PVDF enables generation of electrical charges on its surface upon acoustic stimulation, inducing neuritogenesis of PC12 cells. We demonstrate that the effect of pure piezoelectric stimulation on neurite generation in PC12 cells is comparable to the ones induced by neuronal growth factor (NGF). In inhibitor experiments, our results indicate that dynamic stimulation of PVDF by ultrasonic (US) waves activates calcium channels, thus inducing the generation of neurites via a cyclic adenosine monophosphate (cAMP)-dependent pathway. This mechanism is independent from the well-studied NGF induced mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) pathway. The use of US, in combination with piezoelectric polymers, is advantageous since focused power transmission can occur deep into biological tissues, which holds great promise for the development of non-invasive neuroregenerative devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.