Evidence map›Paper›PMID 28642369›Full record

ArticleThe Journal of biological chemistry2017

Replisome-mediated translesion synthesis by a cellular replicase.

Philip Nevin, Carolina C Gabbai, Kenneth J Marians

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
7.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Direct visualization of translesion DNA synthesis polymerase IV at the replisome.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  3. Review
  4. Article
  5. A Comprehensive View of Translesion Synthesis in Escherichia coli.Microbiology and molecular biology reviews : MMBR · 2020
    Review
  6. A gatekeeping function of the replicative polymerase controls pathway choice in the resolution of lesion-stalled replisomes.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Philip NevinFrom the Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065.
Carolina C GabbaiFrom the Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065.
Kenneth J MariansFrom the Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065 kmarians@sloankettering.edu.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
MECHANISMS OF DNA REPLICATIONR37GM034557 · NIGMS · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI MARIANS, KENNETH J · 2001 to 2010
$5.8M
MECHANISMS OF LAGGING STRAND SYNTHESISR01GM034557 · NIGMS · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI MARIANS, KENNETH J · 1985 to 2018
$5.7M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM034557NIGMS NIH HHS R37 GM034557
6 · The paper itself

Abstract

Genome integrity relies on the ability of the replisome to navigate ubiquitous DNA damage during DNA replication. The

Indexed as

DNA Breaks, Single-StrandedDNA ReplicationDNA, BacterialDNA-Directed DNA PolymeraseDNA Polymerase IIIEscherichia coliEscherichia coli ProteinsFrameshift MutationFuransHoloenzymesMultienzyme ComplexesProtein MultimerizationPyrimidine DimersReplication OriginReplisomesDNA, BacterialDNA-Directed DNA PolymeraseDNA Polymerase IIIDNA replicaseEscherichia coli ProteinsFuransHoloenzymesMultienzyme ComplexesPyrimidine DimersReplisomestetrahydrofuranDNADNA damageDNA enzymeDNA polymeraseDNA repairDNA replication

Identifiers

PMID28642369
PMCPMC5566535
OpenAlexW2711675708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.