ArticleCirculation2017
Dedifferentiation, Proliferation, and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04011059 (Randomized Study as Proof of Concept of Coronary Revascularization Surgery With Injection of Wharton's Jelly-derived Mesenchymal Cells and Placement of an Epicardial Extracellular Matrix Patch Seeded With WJ-MSCs in Patients With Ischemic Cardiomyopathy), which is not on this map. Cited by 139 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 2 pooled it
13.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT04011059 phase1 / phase2unknown statusnot on this mapstarted 2019, after this paper: background citation
Randomized Study as Proof of Concept of Coronary Revascularization Surgery With Injection of Wharton's Jelly-derived Mesenchymal Cells and Placement of an Epicardial Extracellular Matrix Patch Seeded With WJ-MSCs in Patients With Ischemic Cardiomyopathy
Who cites it
139 citing papers in PubMed, 2 syntheses or guidelines pooled it, 219 citations in OpenAlex.
- A meta-analysis and systematic review of myocardial infarction-induced cardiomyocyte proliferation in adult mouse heart.BMC medicine · 2024Pooled it
- Electrical stimulation through conductive scaffolds for cardiomyocyte tissue engineering: Systematic review and narrative synthesis.Annals of the New York Academy of Sciences · 2022Pooled it
- Epigenetic Control of Mammalian Cardiomyocyte Proliferation.Current cardiology reports · 2026Review
- Targeted delivery of USP10 via neutrophil membrane-coated biomimetic nanoparticle facilitates cardiac repair through AMPK-dependent anti-apoptotic and pro-angiogenic pathways.Journal of translational medicine · 2026Article
- Article
- Retinol saturase in the mitochondria antagonizes IDH2 and GLUD1 acetylation to mediate heart repair.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Human Hearts Intrinsically Increase Cardiomyocyte Mitosis After Myocardial Infarction.Circulation research · 2026Article
- Insights into Cardiomyocyte Regeneration from Screening and Transcriptomics Approaches.International journal of molecular sciences · 2026Review
- AAV6-based ZEB2 delivery promotes cardiomyocyte dedifferentiation in adult human myocardium.Cardiovascular research · 2025Article
- Identification of LncRNA Mhrt as a potential biomarker for preventing the progression of Myocardial Ischemia-Reperfusion Injury through bioinformatics and experimental validation.BMC cardiovascular disorders · 2025Article
- Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation.Nature reviews. Cardiology · 2025Review
- Cited4a limits cardiomyocyte dedifferentiation and proliferation during zebrafish heart regeneration.Development (Cambridge, England) · 2025Article
- Rewiring cell identity and metabolism to drive cardiomyocyte proliferation.Cell regeneration (London, England) · 2025Review
- Review
- Peripheral blood mesenchymal stem cell-derived exosomes improve renal sympathetic denervation efficacy through β-catenin-mediated cardiac reprogramming.Clinical and translational medicine · 2025Article
- Integrated proteomics identifies troponin I isoform switch as a regulator of a sarcomere-metabolism axis during cardiac regeneration.Cardiovascular research · 2025Article
- Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation.Cell communication and signaling : CCS · 2025Article
- The drug-elicitable alternative splicing module for tunable vector expression in the heart.Nature cardiovascular research · 2025Article
- Triiodothyronine protects infarcted myocardium by reducing apoptosis and preserving mitochondria.Basic research in cardiology · 2025Article
- LncRNA SNHG15 promotes angiogenesis and improves cardiac repair after myocardial infarction through MiR-665-mediated KDR expression.Cellular and molecular life sciences : CMLS · 2025Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Wei Eric WangFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Liangpeng LiFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Xuewei XiaFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Wenbin FuFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Qiao LiaoFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Cong LanFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Dezhong YangFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Hongmei ChenFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Rongchuan YueFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Cindy ZengFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Lin ZhouFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Bin ZhouFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Dayue Darrel DuanFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.).
Xiongwen ChenFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.). chunyuzeng01@163.com srhouser@temple.edu xchen001@temple.edu.
Steven R HouserFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.). chunyuzeng01@163.com srhouser@temple.edu xchen001@temple.edu.
Chunyu ZengFrom Department of Cardiology, Chongqing Institute of Cardiology and Chongqing Cardiovascular Clinical Research Center, Daping Hospital, Third Military Medical University, China (W.E.W., L.L., X.X., W.F., Q.L., C.L., D.Y., H.C., R.Y., C.S.Z., L.Z., X.C., C.Z.); State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (B.Z.); Laboratory of Cardiovascular Phenomics, Center for Molecular Medicine, Department of Pharmacology, University of Nevada School of Medicine, Reno (D.D.D.); and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (X.C., S.R.H.). chunyuzeng01@163.com srhouser@temple.edu xchen001@temple.edu.
University of Chinese Academy of Sciences · CNUniversity of Nevada, Reno · USCenter for Excellence in Molecular Cell Science · CNShanghai Institutes for Biological Sciences · CN
Funding
Targeted Cancer Therapeutics and Heart Failure: Mechanisms and Post-injury RepairP01HL091799 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI KOCH, WALTER J. · 2008 to 2018
$23.1MCalcium and Cardiac Regeneration after Myocardial InfarctionR01HL033921 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 1985 to 2017
$5.6MProtein Kinase A Inhibitor Peptide (PKI) and Cardiac Protection in Heart FailureR01HL088243 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CHEN, XIONGWEN · 2007 to 2017
$4.0MCa2+ Regulation in Newly Formed Ventricular MyocytesR37HL033921 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 2009 to 2013
$2.2MThe CLC-3 chloride channels in the heartR01HL113598 · NHLBI · UNIVERSITY OF NEVADA RENO · PI DUAN, DAYUE DARREL · 2013 to 2016
$1.4MNHLBI NIH HHS P01 HL091799NHLBI NIH HHS R01 HL033921NHLBI NIH HHS R01 HL088243NHLBI NIH HHS R01 HL113598NHLBI NIH HHS R37 HL033921
Abstract
backgroundAdult mammalian hearts have a limited ability to generate new cardiomyocytes. Proliferation of existing adult cardiomyocytes (ACMs) is a potential source of new cardiomyocytes. Understanding the fundamental biology of ACM proliferation could be of great clinical significance for treating myocardial infarction (MI). We aim to understand the process and regulation of ACM proliferation and its role in new cardiomyocyte formation of post-MI mouse hearts.
methodsβ-Actin-green fluorescent protein transgenic mice and fate-mapping Myh6-MerCreMer-tdTomato/lacZ mice were used to trace the fate of ACMs. In a coculture system with neonatal rat ventricular myocytes, ACM proliferation was documented with clear evidence of cytokinesis observed with time-lapse imaging. Cardiomyocyte proliferation in the adult mouse post-MI heart was detected by cell cycle markers and 5-ethynyl-2-deoxyuridine incorporation analysis. Echocardiography was used to measure cardiac function, and histology was performed to determine infarction size.
resultsIn vitro, mononucleated and bi/multinucleated ACMs were able to proliferate at a similar rate (7.0%) in the coculture. Dedifferentiation proceeded ACM proliferation, which was followed by redifferentiation. Redifferentiation was essential to endow the daughter cells with cardiomyocyte contractile function. Intercellular propagation of Ca
conclusionsMature ACMs can reenter the cell cycle and form new cardiomyocytes through a 3-step process: dedifferentiation, proliferation, and redifferentiation. Intercellular Ca
Indexed as
AnimalsCell DifferentiationCell ProliferationCells, CulturedCell SurvivalConnexin 43CytokinesisEchocardiographyGap JunctionsHeartHumansMiceMice, TransgenicMyocardial InfarctionMyocardiumMyocytes, CardiacConnexin 43Troponin Icell dedifferentiationcellular proliferationmyocardial infarctionmyocytes, cardiacredifferentiation
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Registered trials
NCT04011059ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.