Evidence map›Paper›PMID 28642246›Full record

ArticleCancer immunology research2017

Modulation of Endoplasmic Reticulum Stress Controls CD4

Jessica E Thaxton, Caroline Wallace, Brian Riesenberg, Yongliang Zhang, Chrystal M Paulos, Craig C Beeson, Bei Liu, Zihai Li

Open access · greenAbstract read
In one paragraph

Article in Cancer immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Quercetin ameliorates aflatoxin BJournal of animal science and biotechnology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Unfolded protein responses in T cell immunity.Frontiers in immunology · 2024
    Review
  12. Proteostasis in T cell aging.Seminars in immunology · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. mTOR pathway mediates endoplasmic reticulum stress-induced CD4Apoptosis : an international journal on programmed cell death · 2022
    Article
  17. Review
  18. Review
  19. Article
  20. Endoplasmic Reticulum Quality Control in Immune Cells.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Jessica E ThaxtonDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.
Caroline WallaceDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.
Brian RiesenbergDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.
Yongliang ZhangDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.
Chrystal M PaulosDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.
Craig C BeesonDepartment of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina.
Bei LiuDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.
Zihai LiDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina. zihai@musc.edu.
Medical University of South Carolina · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2012 to 2020
$20.2M
Project 3: Structural Basis for grp94 Drug Development and Chaperone FunctionP01CA186866 · NCI · OHIO STATE UNIVERSITY · PI GEWIRTH, DANIEL T · 2015 to 2019
$6.7M
MUSC/HCC Paul Calabresi Clinical Oncology Training Program PlanK12CA157688 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LOCKHART, ALBERT CRAIG, WRANGLE, JOHN M. · 2013 to 2022
$4.3M
Roles and Mechanisms of gp96 in Chaperoning Innate ImmunityR01AI070603 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LI, ZIHAI · 2007 to 2016
$3.8M
Molecular chaperones and immune toleranceR01AI077283 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LI, ZIHAI · 2009 to 2021
$3.7M
Extrinsic and intrinsic factors regulating commensal-specific T helper-17 cellsU01AI125859 · NIAID · OHIO STATE UNIVERSITY · PI LIU, BEI · 2016 to 2020
$2.5M
Thrombocytes in Cancer ImmunityR01CA188419 · NCI · OHIO STATE UNIVERSITY · PI LI, ZIHAI · 2015 to 2019
$1.9M
Mechanism of gp96/grp94 in regulating plasma cells and myelomaR01CA193939 · NCI · OHIO STATE UNIVERSITY · PI LIU, BEI · 2016 to 2020
$1.7M
NCI NIH HHS P01 CA186866NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA188419NCI NIH HHS R01 CA193939NIAID NIH HHS R01 AI070603NIAID NIH HHS R01 AI077283NIAID NIH HHS U01 AI125859NIGMS NIH HHS P20 GM103542
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) is an energy-sensing organelle with intimate ties to programming cell activation and metabolic fate. T-cell receptor (TCR) activation represents a form of acute cell stress and induces mobilization of ER Ca

Indexed as

CalciumCD4-Positive T-LymphocytesEndoplasmic Reticulum StressGlycolysisHumansHyaluronan ReceptorsInositol 1,4,5-Trisphosphate ReceptorsL-SelectinLymphocyte ActivationMembrane GlycoproteinsNeoplasmsReceptors, Antigen, T-CellCalciumendoplasminHyaluronan ReceptorsInositol 1,4,5-Trisphosphate ReceptorsL-SelectinMembrane GlycoproteinsReceptors, Antigen, T-Cell

Identifiers

PMID28642246
PMCPMC5585019
OpenAlexW2640539889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.