Evidence map›Paper›PMID 28642212›Full record

ArticleJMIR public health and surveillance2017

Filtering Entities to Optimize Identification of Adverse Drug Reaction From Social Media: How Can the Number of Words Between Entities in the Messages Help?

Redhouane Abdellaoui, Stéphane Schück, Nathalie Texier, Anita Burgun

Open access · goldAbstract read
In one paragraph

Article in JMIR public health and surveillance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 36 citations in OpenAlex.

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  11. Infodemiology and Infoveillance: Scoping Review.Journal of medical Internet research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Redhouane AbdellaouiINSERM, UMRS 1138 Team 22, Université Pierre et Marie Curie, Paris, France.ORCID http://orcid.org/0000-0002-2938-7478
Stéphane SchückKappa Santé, Innovation, Paris, France.ORCID http://orcid.org/0000-0003-2642-7726
Nathalie TexierKappa Santé, Innovation, Paris, France.ORCID http://orcid.org/0000-0003-3749-254X
Anita BurgunINSERM, UMRS 1138 Team 22, Université Pierre et Marie Curie, Paris, France.ORCID http://orcid.org/0000-0001-6855-4366
Délégation Paris 5 · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith the increasing popularity of Web 2.0 applications, social media has made it possible for individuals to post messages on adverse drug reactions. In such online conversations, patients discuss their symptoms, medical history, and diseases. These disorders may correspond to adverse drug reactions (ADRs) or any other medical condition. Therefore, methods must be developed to distinguish between false positives and true ADR declarations.

objectiveThe aim of this study was to investigate a method for filtering out disorder terms that did not correspond to adverse events by using the distance (as number of words) between the drug term and the disorder or symptom term in the post. We hypothesized that the shorter the distance between the disorder name and the drug, the higher the probability to be an ADR.

methodsWe analyzed a corpus of 648 messages corresponding to a total of 1654 (drug and disorder) pairs from 5 French forums using Gaussian mixture models and an expectation-maximization (EM) algorithm .

resultsThe distribution of the distances between the drug term and the disorder term enabled the filtering of 50.03% (733/1465) of the disorders that were not ADRs. Our filtering strategy achieved a precision of 95.8% and a recall of 50.0%.

conclusionsThis study suggests that such distance between terms can be used for identifying false positives, thereby improving ADR detection in social media.

Indexed as

clusteringdensity estimationEM algorithmGaussian mixture modelpharmacovigilancesocial mediatext mining

Identifiers

PMID28642212
PMCPMC5500778
OpenAlexW2715985536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.