Trial reportContemporary clinical trials2017
The INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) study: Design and methods to address mental healthcare gaps in India.
Trial report in Contemporary clinical trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02022111 (INtegrating DEPrEssioN and Diabetes treatmENT), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) Study
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Primary-level worker interventions for the care of people living with mental disorders and distress in low- and middle-income countries.The Cochrane database of systematic reviews · 2021Pooled it
- The Influence of Depression, Positive Health Behaviors, and Weight Status on Glycated Hemoglobin: A Sequential Mediation Analysis of the INDEPENDENT Trial.Journal of general internal medicine · 2025Trial
- Factors influencing diabetes treatment satisfaction in the INtegrating DEPrEssioN and Diabetes treatmENT randomized clinical trial: A multilevel model analysis.Diabetic medicine : a journal of the British Diabetic Association · 2024Trial
- Association of collaborative care intervention features with depression and metabolic outcomes in the INDEPENDENT study: A mixed methods study.Primary care diabetes · 2024Trial
- Long-term Effects of a Collaborative Care Model on Metabolic Outcomes and Depressive Symptoms: 36-Month Outcomes from the INDEPENDENT Intervention.Journal of general internal medicine · 2023Trial
- Cost-Effectiveness of a Collaborative Care Model Among Patients With Type 2 Diabetes and Depression in India.Diabetes care · 2023Trial
- Trial
- Effect of a collaborative care model on anxiety symptoms among patients with depression and diabetes in India: The INDEPENDENT randomized clinical trial.General hospital psychiatryTrial
- Predicting control of cardiovascular disease risk factors in South Asia using machine learning.NPJ digital medicine · 2024Article
- Healthcare dashboard technologies and data visualization for lipid management: A scoping review.BMC medical informatics and decision making · 2024Article
- A mediation analysis evaluating change in self-stigma on diabetes outcomes among people with depression in urban India: A secondary analysis from the INDEPENDENT trial of the collaborative care model.PLOS global public health · 2024Article
- A Strategic Research Framework for Defeating Diabetes in India: A 21st-Century Agenda.Journal of the Indian Institute of Science · 2023Review
- A realist process evaluation of the INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) randomized controlled trial in India.American journal of medicine open · 2022Article
- Stakeholder Perspectives regarding the Acceptability and Sustainability of a Multi-component Diabetes Care Strategy in South Asia: a longitudinal qualitative analysis.Global implementation research and applications · 2022Article
- Metformin for the Improvement of Comorbid Depression Symptoms in Diabetic Patients: A Systematic Review.Cureus · 2022Review
- Can the management of depression in type 2 diabetes be democratized?World journal of diabetes · 2022Review
- Elements and Performance Indicators of Integrated Healthcare Programmes on Chronic Diseases in Six Countries in the Asia-Pacific Region: A Scoping Review.International journal of integrated care · 2021Article
- Factors that facilitate patient activation in the self-management of diabetes and depression among participants enrolled in an integrated chronic care model in India.Social science & medicine (1982) · 2021Article
- Patient-reported outcomes for diabetes and hypertension care in low- and middle-income countries: A scoping review.PloS one · 2021Article
- The Integrated Tracking, Referral, and Electronic Decision Support, and Care Coordination (I-TREC) program: scalable strategies for the management of hypertension and diabetes within the government healthcare system of India.BMC health services research · 2020Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
Abstract
introductionDepression and diabetes are highly prevalent worldwide and often co-exist, worsening outcomes for each condition. Barriers to diagnosis and treatment are exacerbated in low and middle-income countries with limited health infrastructure and access to mental health treatment. The INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) study tests the sustained effectiveness and cost-effectiveness of a multi-component care model for individuals with poorly-controlled diabetes and depression in diabetes clinics in India. MATERIALS AND
methodsAdults with diabetes, depressive symptoms (Patient Health Questionnaire-9 score≥10), and ≥1 poorly-controlled cardiometabolic indicator (either HbA1c≥8.0%, SBP≥140mmHg, and/or LDL≥130mg/dl) were enrolled and randomized to the intervention or usual care. The intervention combined collaborative care, decision-support, and population health management. The primary outcome is the between-arm difference in the proportion of participants achieving combined depression response (≥50% reduction in Symptom Checklist score from baseline) AND one or more of: ≥0.5% reduction in HbA1c, ≥5mmHg reduction in SBP, or ≥10mg/dl reduction in LDL-c at 24months (12-month intervention; 12-month observational follow-up). Other outcomes include control of individual parameters, patient-centered measures (i.e. treatment satisfaction), and cost-effectiveness.
resultsThe study trained seven care coordinators. Participant recruitment is complete - 940 adults were screened, with 483 eligible, and 404 randomized (196 to intervention; 208 to usual care). Randomization was balanced across clinic sites.
conclusionsThe INDEPENDENT model aims to increase access to mental health care and improve depression and cardiometabolic disease outcomes among complex patients with diabetes by leveraging the care provided in diabetes clinics in India (clinicaltrials.gov number: NCT02022111).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.