ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2018
A comprehensive model for heat-induced radio-sensitisation.
Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Radioenhancement with the Combination of Docetaxel and Ultrasound Microbubbles: In Vivo Prostate Cancer.Pharmaceutics · 2023Article
- Microwave Radiation and the Brain: Mechanisms, Current Status, and Future Prospects.International journal of molecular sciences · 2022Review
- Design and Characterization of an RF Applicator for In Vitro Tests of Electromagnetic Hyperthermia.Sensors (Basel, Switzerland) · 2022Article
- Mathematical model for the thermal enhancement of radiation response: thermodynamic approach.Scientific reports · 2021Article
- Holistic View on Cell Survival and DNA Damage: How Model-Based Data Analysis Supports Exploration of Dynamics in Biological Systems.Computational and mathematical methods in medicine · 2020Article
- Focused Ultrasound-Mediated Hyperthermia in Vitro: An Experimental Arrangement for Treating Cells under Tissue-Mimicking Conditions.Ultrasound in medicine & biology · 2019Article
- A cellular automaton model for spheroid response to radiation and hyperthermia treatments.Scientific reports · 2019Article
- Response to comment by G. Borasi.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2018Article
- Combining radiation with hyperthermia: a multiscale model informed byJournal of the Royal Society, Interface · 2018Article
- Modulated Electro-Hyperthermia as Palliative Treatment for Pancreatic Cancer: A Retrospective Observational Study on 106 Patients.Integrative cancer therapiesObservational
- A Narrative Review of Regional Hyperthermia: Updates From 2010 to 2019.Integrative cancer therapiesReview
- Modulated Electrohyperthermia in Integrative Cancer Treatment for Relapsed Malignant Glioblastoma and Astrocytoma: Retrospective Multicenter Controlled Study.Integrative cancer therapiesObservational
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6 authors.
Funding
Abstract
Combined radiotherapy (RT) and hyperthermia (HT) treatments may improve treatment outcome by heat induced radio-sensitisation. We propose an empirical cell survival model (AlphaR model) to describe this multimodality therapy. The model is motivated by the observation that heat induced radio-sensitisation may be explained by a reduction in the DNA damage repair capacity of heated cells. We assume that this repair is only possible up to a threshold level above which survival will decrease exponentially with dose. Experimental cell survival data from two cell lines (HCT116, Cal27) were considered along with that taken from the literature (baby hamster kidney [BHK] and Chinese hamster ovary cells [CHO]) for HT and combined RT-HT. The AlphaR model was used to study the dependence of clonogenic survival on treatment temperature, and thermal dose R
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