Evidence map›Paper›PMID 28641043›Full record

ArticleRadiology2017

Radiogenomics of High-Grade Serous Ovarian Cancer: Multireader Multi-Institutional Study from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group.

Hebert Alberto Vargas, Erich P Huang, Yulia Lakhman, Joseph E Ippolito, Priya Bhosale, Vincent Mellnick, Atul B Shinagare, Maria Anello, Justin Kirby, Brenda Fevrier-Sullivan and 3 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. TCGA-TCIA Impact on Radiogenomics Cancer Research: A Systematic Review.International journal of molecular sciences · 2019
    Pooled it
  2. Article
  3. Radiomics and radiogenomics in ovarian cancer: a review with a focus on ultrasound applications.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Review
  4. Review
  5. Article
  6. Staging by imaging in gynecologic cancer and the role of ultrasound: an update of European joint consensus statements.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2024
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Ovarian cancer staging: What the surgeon needs to know.The British journal of radiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Hebert Alberto VargasFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Erich P HuangFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Yulia LakhmanFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Joseph E IppolitoFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Priya BhosaleFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Vincent MellnickFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Atul B ShinagareFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Maria AnelloFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Justin KirbyFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Brenda Fevrier-SullivanFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
John FreymannFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
C Carl JaffeFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Evis SalaFrom the Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C278, New York, NY 10065 (H.A.V., Y.L., E.S.); Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Rockville, Md (E.P.H.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (J.E.I., V.M.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (P.B.); Department of Imaging, Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.S.); Department of Radiology, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pa (M.A.); Leidos Biomedical Research, National Cancer Institute, National Institutes of Health, Frederick, Md (J.K., B.F.S., J.F.); and Department of Radiology, Boston University School of Medicine, Boston, Mass (C.C.J.).
Memorial Sloan Kettering Cancer Center · USNational Institutes of Health · USMallinckrodt (United States) · USBoston University · USLeidos (United States) · USMagee-Womens Hospital · USThe University of Texas MD Anderson Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Purpose To evaluate interradiologist agreement on assessments of computed tomography (CT) imaging features of high-grade serous ovarian cancer (HGSOC), to assess their associations with time-to-disease progression (TTP) and HGSOC transcriptomic profiles (Classification of Ovarian Cancer [CLOVAR]), and to develop an imaging-based risk score system to predict TTP and CLOVAR profiles. Materials and Methods This study was a multireader, multi-institutional, institutional review board-approved, HIPAA-compliant retrospective analysis of 92 patients with HGSOC (median age, 61 years) with abdominopelvic CT before primary cytoreductive surgery available through the Cancer Imaging Archive. Eight radiologists from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group developed and independently recorded the following CT features: characteristics of primary ovarian mass(es), presence of definable mesenteric implants and infiltration, presence of other implants, presence and distribution of peritoneal spread, presence and size of pleural effusions and ascites, lymphadenopathy, and distant metastases. Interobserver agreement for CT features was assessed, as were univariate and multivariate associations with TTP and CLOVAR mesenchymal profile (worst prognosis). Results Interobserver agreement for some features was strong (eg, α = .78 for pleural effusion and ascites) but was lower for others (eg, α = .08 for intraparenchymal splenic metastases). Presence of peritoneal disease in the right upper quadrant (P = .0003), supradiaphragmatic lymphadenopathy (P = .0004), more peritoneal disease sites (P = .0006), and nonvisualization of a discrete ovarian mass (P = .0037) were associated with shorter TTP. More peritoneal disease sites (P = .0025) and presence of pouch of Douglas implants (P = .0045) were associated with CLOVAR mesenchymal profile. Combinations of imaging features contained predictive signal for TTP (concordance index = 0.658; P = .0006) and CLOVAR profile (mean squared deviation = 1.776; P = .0043). Conclusion These results provide some evidence of the clinical and biologic validity of these image features. Interobserver agreement is strong for some features, but could be improved for others.

Indexed as

FemaleGenomicsHumansMiddle AgedOvarian NeoplasmsRetrospective StudiesTomography, X-Ray Computed

Identifiers

PMID28641043
PMCPMC5673051
OpenAlexW2671677316

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.