ArticlePlant biotechnology journal2018
RESISTANCE TO POWDERY MILDEW8.1 boosts pattern-triggered immunity against multiple pathogens in Arabidopsis and rice.
Article in Plant biotechnology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Identification of the NBS-LRR gene family and AkNBS-LRR43 and 100 functional analysis under biotic stress.Plant cell reports · 2026Article
- A century of advances in molecular genetics and breeding for sustainable resistance to rice blast disease.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Article
- Broad-spectrum resistance gene RPW8.1 balances immunity and growth via feedback regulation of WRKYs.Plant biotechnology journal · 2024Article
- Overexpression of ATP Synthase Subunit Beta (Atp2) Confers Enhanced Blast Disease Resistance in Transgenic Rice.Journal of fungi (Basel, Switzerland) · 2023Article
- Exploring the Biologically Active Metabolites Produced byMetabolites · 2023Article
- Linking plant functional genes to rhizosphere microbes: a review.Plant biotechnology journal · 2023Review
- Osa-miR160a confers broad-spectrum resistance to fungal and bacterial pathogens in rice.The New phytologist · 2022Article
- Ectopic Expression ofInternational journal of molecular sciences · 2022Article
- Comparative Transcriptome Analysis Reveals the Specific Activation of Defense Pathways AgainstFrontiers in plant science · 2022Article
- Genetic Architecture of Powdery Mildew Resistance Revealed by a Genome-Wide Association Study of a Worldwide Collection of Flax (Frontiers in plant science · 2022Article
- Glutamine synthetase geneHorticulture research · 2022Article
- Global whole-genome comparison and analysis to classify subpopulations and identify resistance genes in weedy rice relevant for improving crops.Frontiers in plant science · 2022Article
- Synaptotagmin 5 Controls SYP132-VAMP721/722 Interaction for Arabidopsis Immunity toMolecules and cells · 2021Article
- The Flower-Infecting FungusFrontiers in plant science · 2021Article
- RPW8.1 enhances the ethylene-signaling pathway to feedback-attenuate its mediated cell death and disease resistance in Arabidopsis.The New phytologist · 2021Article
- Overexpression ofFrontiers in plant science · 2019Article
- Expression of a maize NBS gene ZmNBS42 enhances disease resistance in Arabidopsis.Plant cell reports · 2018Article
- Article
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15 authors.
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Abstract
The Arabidopsis gene RESISTANCE TO POWDERY MILDEW8.1 (RPW8.1) confers resistance to virulent fungal and oomycete pathogens that cause powdery mildew and downy mildew, respectively. However, the underlying mechanism remains unclear. Here, we show that ectopic expression of RPW8.1 boosts pattern-triggered immunity (PTI) resulting in enhanced resistance against different pathogens in both Arabidopsis and rice. In Arabidopsis, transcriptome analysis revealed that ectopic expression of RPW8.1-YFP constitutively up-regulates expression of many pathogen-associated molecular pattern (PAMP-)-inducible genes. Consistently, upon PAMP application, the transgenic line expressing RPW8.1-YFP exhibited more pronounced PTI responses such as callose deposition, production of reactive oxygen species, expression of defence-related genes and hypersensitive response-like cell death. Accordingly, the growth of a virulent bacterial pathogen was significantly inhibited in the transgenic lines expressing RPW8.1-YFP. Conversely, impairment of the PTI signalling pathway from PAMP cognition to the immediate downstream relay of phosphorylation abolished or significantly compromised RPW8.1-boosted PTI responses. In rice, heterologous expression of RPW8.1-YFP also led to enhanced resistance to the blast fungus Pyricularia oryzae (syn. Magnaporthe oryzae) and the bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo). Taken together, our data suggest a surprising mechanistic connection between RPW8.1 function and PTI, and demonstrate the potential of RPW8.1 as a transgene for engineering disease resistance across wide taxonomic lineages of plants.
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