ArticleDepression and anxiety2018
Atypical depression and double depression predict new-onset cardiovascular disease in U.S. adults.
Article in Depression and anxiety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 41 citations in OpenAlex.
- A Clinical Study on the Efficacy of the Yangxin Huoxue Formula in Treating Stable Angina Pectoris (Qi Deficiency and Blood Stasis Syndrome) with Concurrent Anxiety and Depression Disorders.Journal of multidisciplinary healthcare · 2024Trial
- Effect of modernized collaborative care for depression on depressive symptoms and cardiovascular disease risk biomarkers: eIMPACT randomized controlled trial.Brain, behavior, and immunity · 2023Trial
- Life's Simple 7, depressive symptoms, cognitive performance, and their associations with all-cause mortality among middle-aged urban adults.GeroScience · 2026Article
- Evidence for overlapping genetic architecture between lifestyle factors and severe mental disorders with different patterns across diagnoses.EBioMedicine · 2026Article
- [Immunometabolic mechanisms in atypical depression].Der Nervenarzt · 2026Review
- Predicting incident cardio-metabolic disease among persons with and without depressive and anxiety disorders: a machine learning approach.Social psychiatry and psychiatric epidemiology · 2025Article
- The Association of Genetic Polymorphisms and Atypical Depression in Adults: A Systematic Review.Clinical neuropsychiatry · 2024Review
- Methods for quantifying the heterogeneity of psychopathology.BMC psychiatry · 2023Article
- The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity.Journal of personalized medicine · 2023Article
- Article
- Metabolomics signatures of depression: the role of symptom profiles.Translational psychiatry · 2023Article
- The Chain-Mediating Effect of Obesity, Depressive Symptoms on the Association between Dietary Quality and Cardiovascular Disease Risk.Nutrients · 2023Article
- How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis.International journal of epidemiology · 2022Article
- Mood and anxiety profiles differentially associate with physical conditions in US adolescents.Journal of affective disorders · 2022Article
- Association of Depressive Symptoms With Incident Cardiovascular Diseases in Middle-Aged and Older Chinese Adults.JAMA network open · 2019Article
- Association of Mental Health Conditions With Participation in Cardiac Rehabilitation.Journal of the American Heart Association · 2019Article
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
backgroundAlthough depression is a risk factor for cardiovascular disease (CVD), it is unknown whether this risk varies across depressive disorder subtypes. Thus, we investigated atypical major depressive disorder (MDD) and double depression as predictors of new-onset CVD in a nationally representative sample of U.S. adults.
methodsProspective data from 28,726 adults initially free of CVD who participated in Wave 1 (2001-2002) and Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were examined. Lifetime depressive disorder subtypes (Wave 1) and incident CVD (Wave 2) were determined by structured interviews.
resultsWe identified 1,116 incident CVD cases. In demographics adjusted models, the atypical MDD group had a higher odds of incident CVD than the no depression history (OR = 2.19, 95% CI: 1.71-2.81, P < .001), dysthymic disorder only (OR = 1.61, 95% CI: 1.08-2.39, P = .019), and nonatypical MDD (OR = 1.46, 95% CI: 1.11-1.91, P = .006) groups. Likewise, the double depression group had a higher odds of incident CVD than the no depression history (OR = 2.17, 95% CI: 1.92-2.45, P < .001), dysthymic disorder only (OR = 1.59, 95% CI: 1.16-2.19, P = .004), and MDD only (OR = 1.46, 95% CI: 1.20-1.77, P < .001) groups. Relationships were similar but attenuated after adjustment for CVD risk factors and anxiety disorders.
conclusionsAdults with atypical MDD or double depression may be subgroups of the depressed population at particularly high risk of new-onset CVD. Thus, these subgroups may (a) be driving the overall depression-CVD relationship and (b) be in need of earlier and/or more intense CVD primary prevention efforts to reduce their excess CVD burden.
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