ArticlePLoS pathogens2017
Competition between influenza A virus subtypes through heterosubtypic immunity modulates re-infection and antibody dynamics in the mallard duck.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Structural insights into antibody responses against influenza A virus in its natural reservoir.bioRxiv : the preprint server for biology · 2026Article
- Long-term immune responses induced by low-dose infection with high pathogenicity avian influenza viruses can protect mallards from reinfection with a heterologous strain.Archives of virology · 2025Article
- Evaluating machine learning approaches for host prediction using H3 influenza genomic data.PloS one · 2025Article
- Influenza A Virus Antibodies in Ducks and Introduction of Highly Pathogenic Influenza A(H5N1) Virus, Tennessee, USA.Emerging infectious diseases · 2024Article
- Highly Pathogenic H5N1 Influenza A Virus (IAV) in Blue-Winged Teal in the Mississippi Flyway Is Following the Historic Seasonal Pattern of Low-Pathogenicity IAV in Ducks.Pathogens (Basel, Switzerland) · 2024Article
- Article
- Genetic Diversity of Avian Influenza Viruses Detected in Waterbirds in Northeast Italy Using Two Different Sampling Strategies.Animals : an open access journal from MDPI · 2024Article
- Intensity and drivers of subtypes interference between seasonal influenza viruses in mainland China: A modeling study.iScience · 2024Article
- Association of biosecurity and hygiene practices with avian influenza A/H5 and A/H9 virus infections in turkey farms.Frontiers in veterinary science · 2024Article
- Ecological and Genetic Landscapes of Global H12 Avian Influenza Viruses and Biological Characteristics of an H12N5 Virus Isolated from Wild Ducks in Eastern China.Transboundary and emerging diseases · 2024Article
- Comparison of respiratory pathogens in children with community-acquired pneumonia before and during the COVID-19 pandemic.BMC pediatrics · 2023Article
- Article
- Lockdown measures during the COVID-19 pandemic strongly impacted the circulation of respiratory pathogens in Southern China.Scientific reports · 2022Article
- Long-Term Protective Effect of Serial Infections with H5N8 Highly Pathogenic Avian Influenza Virus in Wild Ducks.Journal of virology · 2022Article
- Spatiotemporal changes in influenza A virus prevalence among wild waterfowl inhabiting the continental United States throughout the annual cycle.Scientific reports · 2022Article
- Maintenance and dissemination of avian-origin influenza A virus within the northern Atlantic Flyway of North America.PLoS pathogens · 2022Article
- Naturally Acquired Antibodies to Influenza A Virus in Fall-Migrating North American Mallards.Veterinary sciences · 2022Article
- Evolutionary features of a prolific subtype of avian influenza A virus in European waterfowl.Virus evolution · 2022Article
- Comparison of 11 respiratory pathogens among hospitalized children before and during the COVID-19 epidemic in Shenzhen, China.Virology journal · 2021Article
- Impact of Wearing Masks, Hand Hygiene, and Social Distancing on Influenza, Enterovirus, and All-Cause Pneumonia During the Coronavirus Pandemic: Retrospective National Epidemiological Surveillance Study.Journal of medical Internet research · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Our overall hypothesis is that host population immunity directed at multiple antigens will influence the prevalence, diversity and evolution of influenza A virus (IAV) in avian populations where the vast subtype diversity is maintained. To investigate how initial infection influences the outcome of later infections with homologous or heterologous IAV subtypes and how viruses interact through host immune responses, we carried out experimental infections in mallard ducks (Anas platyrhynchos). Mallards were pre-challenged with an H3N8 low-pathogenic IAV and were divided into six groups. At five weeks post H3N8 inoculation, each group was challenged with a different IAV subtype (H4N5, H10N7, H6N2, H12N5) or the same H3N8. Two additional pre-challenged groups were inoculated with the homologous H3N8 virus at weeks 11 and 15 after pre-challenge to evaluate the duration of protection. The results showed that mallards were still resistant to re-infection after 15 weeks. There was a significant reduction in shedding for all pre-challenged groups compared to controls and the outcome of the heterologous challenges varied according to hemagglutinin (HA) phylogenetic relatedness between the viruses used. There was a boost in the H3 antibody titer after re-infection with H4N5, which is consistent with original antigenic sin or antigenic seniority and suggest a putative strategy of virus evasion. These results imply competition between related subtypes that could regulate IAV subtype population dynamics in nature. Collectively, we provide new insights into within-host IAV complex interactions as drivers of IAV antigenic diversity that could allow the circulation of multiple subtypes in wild ducks.
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