ArticlePloS one2017
Dominance of community-associated methicillin-resistant Staphylococcus aureus clones in a maternity hospital.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis.Antimicrobial resistance and infection control · 2021Pooled it
- Methicillin-ResistantToxins · 2020Pooled it
- Molecular epidemiology of methicillin-resistantFrontiers in microbiology · 2025Review
- In-silico and in-vitro study of novel antimicrobial peptide AM1 from Aegle marmelos against drug-resistant Staphylococcus aureus.Scientific reports · 2024Article
- Genetic Complexity of CC5Pathogens (Basel, Switzerland) · 2024Article
- Genomic profiling of methicillin-sensitiveFrontiers in microbiology · 2024Article
- Article
- Multidrug-Resistant Staphylococcus aureus Isolates in a Tertiary Care Hospital, Kingdom of Bahrain.Cureus · 2023Article
- Diversity of clonal complex 22 methicillin-resistantFrontiers in microbiology · 2022Article
- Resurgence of Chloramphenicol Resistance in Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Characterisation of S. aureus/MRSA CC1153 and review of mobile genetic elements carrying the fusidic acid resistance gene fusC.Scientific reports · 2021Article
- Epidemiological typing of methicillin resistantInfection prevention in practice · 2021Article
- Molecular Characterization ofInfection and drug resistance · 2021Article
- Molecular Characterization of Methicillin- Resistant Staphylococcus aureus in a Tertiary Care hospital in Kuwait.Scientific reports · 2019Article
- SCCHeliyon · 2019Article
- Livestock-Associated Methicillin-ResistantFrontiers in microbiology · 2019Article
- Transcriptional Analysis of the Effects of Gambogic Acid and Neogambogic Acid on Methicillin-ResistantFrontiers in pharmacology · 2019Article
- Molecular Characterization of Methicillin ResistantFrontiers in public health · 2019Article
- Molecular Typing of ST239-MRSA-III From Diverse Geographic Locations and the Evolution of the SCCFrontiers in microbiology · 2018Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMethicillin- resistant Staphylococcus aureus (MRSA) is a major pathogen causing healthcare- and community- acquired infections. The purpose of this study was to characterize MRSA isolated at the Maternity Hospital between 2006 and 2011 for their genetic relatedness. MATERIALS AND
methodsThe MRSA isolates were investigated using a combination of antibiogram, Staphylococcal chromosome cassette mec (SCCmec) and spa typing to determine their relatedness to MRSA isolated in other Kuwait hospitals. The isolates were also investigated for the carriage of genes for Pantone valentine Leukocidin (PVL).
resultsA total of 103 MRSA obtained from 64 neonates, 17 adult patients and 12 healthcare workers. The isolates were resistant to Kanamycin (46.6%), gentamicin (40.8%), trimethoprim (32%), ciprofloxacin (22.3%), fusidic acid (16.5%), tetracycline (19.4%), erythromycin (15.5%), clindamycin (15.5%), streptomycin (11.6%) high-level mupirocin (2.9%) and chloramphenicol (0.9%). Twenty (19.4%) of the isolates were multiresistant. Thirty-one (30.0%) isolates were positive for PVL. Molecular typing revealed the presence of 11 clonal complexes and 23 clones with ST5-V-t002, (N = 22), ST22-IV-t223 (N = 18), ST22-IV-t852 (N = 10), ST80-IV-t044 (N = 7), ST5-V-t688 (N = 5), ST772-V-t657 (N = 5) and ST239-III-t860 (N = 4) constituting 66.9% of the isolates. Other clones were isolated sporadically. The number of MRSA isolates increased from two in 2006 to 22 in 2011 with a peak of 43 in 2008.
conclusionThe study revealed a high prevalence of community-associated MRSA Maternity hospital. The MRSA population consisted of known strains, such as ST239-III-t680, ST22-IV-t223/t852 and ST80-IV-t044, that were reported previously in Kuwait and novel strains such as ST5-V-t002, and several sporadic strains obtained for the first time in the Maternity hospital. This study has provided an initial data which will serve as a platform for future comparative studies on the distribution of MRSA clones in the Maternity hospital in Kuwait.
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