ArticlePloS one2017
Toxic effects of atrazine on porcine oocytes and possible mechanisms of action.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Prenatal and postnatal atrazine-induced endocrine and ovarian chemical biotransformation protein disruption in offspring.Journal of the Endocrine Society · 2026Article
- Adverse Effects of Pesticides on the Ovary: Evidence from Epidemiological and Toxicological Studies.Environment & health (Washington, D.C.) · 2025Review
- How Do Environmental Toxicants Affect Oocyte Maturation Via Oxidative Stress?Advances in anatomy, embryology, and cell biology · 2024Review
- Melatonin Supplementation duringAnimals : an open access journal from MDPI · 2023Article
- Atrazine: cytotoxicity, oxidative stress, apoptosis, testicular effects and chemopreventive Interventions.Frontiers in toxicology · 2023Review
- Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature.Current environmental health reports · 2022Review
- Low-Level Groundwater Atrazine in High Atrazine Usage Nebraska Counties: Likely Effects of Excessive Groundwater Abstraction.International journal of environmental research and public health · 2021Article
- Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress.Bioscience reports · 2021Article
- Procyanidin B1 promotes in vitro maturation of pig oocytes by reducing oxidative stress.Molecular reproduction and development · 2021Article
- Induction of Oxidative Stress and Mitochondrial Dysfunction by Juglone Affects the Development of Bovine Oocytes.International journal of molecular sciences · 2020Article
- The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF.Endocrine connections · 2020Review
- Glycyrrhizic acid modulates the atrazine-induced apoptosis in rabbit spleen.Environmental science and pollution research international · 2019Article
- Responses of morphological, physiological, and biochemical characteristics of maize (Zea mays L.) seedlings to atrazine stress.Environmental monitoring and assessment · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because atrazine is a widely used herbicide, its adverse effects on the reproductive system have been extensively researched. In this study, we investigated the effects of atrazine exposure on porcine oocyte maturation and the possible mechanisms. Our results showed that the rates of oocyte maturation significantly decreased after treatment with 200 μM atrazine in vitro. Atrazine treatment resulted in abnormal spindle morphology but did not affect actin distribution. Atrazine exposure not only triggered a DNA damage response but also decreased MPF levels in porcine oocytes. Our results also revealed that atrazine worsened porcine oocyte quality by causing excessive accumulation of superoxide radicals, increasing cathepsin B activity, and decreasing the GSH level and mitochondrial membrane potential. Furthermore, atrazine decreased developmental competence of porcine oocytes up to the blastocyst stage and changed some properties: cell numbers, apoptosis, and related gene expression levels. Collectively, our results indicate that porcine oocyte maturation is defective after atrazine treatment at least through disruption of spindle morphology, MPF activity, and mitochondrial function and via induction of DNA damage, which probably reduces developmental competence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.