ArticlePloS one2017
An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Transcranial Calcium Macro-Imaging From the Auditory Cortex of Thy1-Cre-Driven GCaMP8 Transgenic Rats.Neuropsychopharmacology reports · 2026Article
- Top-down modulation of sensory processing and mismatch in the mouse posterior parietal cortex.Nature communications · 2025Article
- Transcriptional determinants of goal-directed learning and representational drift in the parahippocampal cortex.Cell reports · 2025Article
- Integrated information theory reveals the potential role of the posterior parietal cortex in sustaining conditioning responses in classical conditioning tasks.Frontiers in neuroscience · 2025Article
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- Wide-field imaging in behaving mice as a tool to study cognitive function.Neurophotonics · 2024Review
- Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1.Molecular therapy. Nucleic acids · 2023Article
- Epidermal Growth Factor Receptors in Vascular Endothelial Cells Contribute to Functional Hyperemia in the Brain.International journal of molecular sciences · 2023Article
- Effective and efficient neural networks for spike inference fromCell reports methods · 2023Article
- Panoramic visual statistics shape retina-wide organization of receptive fields.Nature neuroscience · 2023Article
- Review
- Fluorescent protein transgenic mice for the study of CaFree radical biology & medicine · 2022Review
- A Flp-dependent G-CaMP9a transgenic mouse for neuronal imagingCell reports methods · 2022Article
- Article
- A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging.Nature neuroscience · 2021Article
- Article
- Using Genetically Encoded Calcium Indicators to Study Astrocyte Physiology: A Field Guide.Frontiers in cellular neuroscience · 2021Article
- Infrared Excitation Induces Heating and Calcium Microdomain Hyperactivity in Cortical Astrocytes.Biophysical journal · 2020Article
- Context-Dependent Sensory Processing across Primary and Secondary Somatosensory Cortex.Neuron · 2020Article
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14 authors.
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Abstract
Genetically encoded calcium indicators (GECIs) enable imaging of in vivo brain cell activity with high sensitivity and specificity. In contrast to viral infection or in utero electroporation, indicator expression in transgenic reporter lines is induced noninvasively, reliably, and homogenously. Recently, Cre/tTA-dependent reporter mice were introduced, which provide high-level expression of green fluorescent GECIs in a cell-type-specific and inducible manner when crossed with Cre and tTA driver mice. Here, we generated and characterized the first red-shifted GECI reporter line of this type using R-CaMP1.07, a red fluorescent indicator that is efficiently two-photon excited above 1000 nm. By crossing the new R-CaMP1.07 reporter line to Cre lines driving layer-specific expression in neocortex we demonstrate its high fidelity for reporting action potential firing in vivo, long-term stability over months, and versatile use for functional imaging of excitatory neurons across all cortical layers, especially in the previously difficult to access layers 4 and 6.
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