ArticlePLoS neglected tropical diseases2017
Challenges in preparing and implementing a clinical trial at field level in an Ebola emergency: A case study in Guinea, West Africa.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Operational strategies among infectious disease clinical trial sites during pandemics: a scoping review.Trials · 2026Article
- Informed consent and risk communication challenges in antimicrobial clinical trials: a scoping review.BMJ open · 2024Article
- Navigating the challenges of clinical trial professionals in the healthcare sector.Frontiers in medicine · 2024Review
- Challenges and solutions in clinical research during the COVID-19 pandemic: A narrative review.Health science reports · 2023Article
- Article
- How can community engagement in health research be strengthened for infectious disease outbreaks in Sub-Saharan Africa? A scoping review of the literature.BMC public health · 2021Article
- Quantification of Ebola virus replication kinetics in vitro.PLoS computational biology · 2020Article
- Addressing challenges for clinical research responses to emerging epidemics and pandemics: a scoping review.BMC medicine · 2020Article
- The Plasma Mobile, 'A gift from heaven': The impact of health technology transfer on trial perceptions and expectations during the Ebola-Tx Trial, Conakry.PLoS neglected tropical diseases · 2020Article
- A systematic literature review of the ethics of conducting research in the humanitarian setting.Conflict and health · 2020Article
- [Epidemic and emerging prone-infectious diseases: Lessons learned and ways forward].Presse medicale (Paris, France : 1983) · 2019Review
- Suboptimal Handling of Piccolo Samples or Reagent Discs for Consideration in Ebola Response.Emerging infectious diseases · 2019Article
- Ethics preparedness: facilitating ethics review during outbreaks - recommendations from an expert panel.BMC medical ethics · 2019Article
- Catching Chances: The Movement to Be on the Ground and Research Ready before an Outbreak.Viruses · 2018Review
- Consent concerns in clinical trials of investigational therapies for COVID-19: Vulnerability versus voluntariness.Perspectives in clinical researchArticle
- Clinical trials during the COVID-19 pandemic: Challenges of putting scientific and ethical principles into practice.Perspectives in clinical researchArticle
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the large Ebola outbreak that affected West Africa in 2014 and 2015, studies were launched to evaluate potential treatments for the disease. A clinical trial to evaluate the effectiveness of the antiviral drug favipiravir was conducted in Guinea. This paper describes the main challenges of the implementation of the trial in the Ebola treatment center of Guéckédou. Following the principles of the Good Clinical Research Practices, we explored the aspects of the community's communication and engagement, ethical conduct, trial protocol compliance, informed consent of participants, ongoing benefit/risk assessment, record keeping, confidentiality of patients and study data, and roles and responsibilities of the actors involved. We concluded that several challenges have to be addressed to successfully implement a clinical trial during an international medical emergency but that the potential for collaboration between research teams and humanitarian organizations needs to be highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.