ArticleGut microbes2017
An unexplored brain-gut microbiota axis in stroke.
Article in Gut microbes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Procalcitonin and biomarkers for stroke-associated pneumonia: a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- Effect ofInternational journal of medical sciences · 2026Trial
- Gut dysbiosis, metabolic signals, and pulmonary immune reprogramming: decoding the gut microbiota -immune axis in stroke-associated pneumonia.Frontiers in immunology · 2026Review
- Brain heart crosstalk after ischemic stroke toward a unified framework for pathophysiology and precision medicine.Frontiers in molecular neuroscience · 2026Review
- Recent advances on immunity and hypertension: the new cells on the kidney block.American journal of physiology. Renal physiology · 2025Review
- Gut microbiota dysbiosis drives stroke-associated pneumonia: mechanisms and targeted therapeutic strategies.Frontiers in neuroscience · 2025Review
- Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review.Drug design, development and therapy · 2025Review
- Gut Microbiota, Bacterial Translocation, and Stroke: Current Knowledge and Future Directions.Biomedicines · 2024Review
- Gut Bacteria Provide Genetic and Molecular Reporter Systems to Identify Specific Diseases.International journal of molecular sciences · 2024Review
- Stroke Related Brain-Heart Crosstalk: Pathophysiology, Clinical Implications, and Underlying Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Genetically supported causality between gut microbiota, immune cells, and ischemic stroke: a two-sample Mendelian randomization study.Frontiers in microbiology · 2024Article
- Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites.Translational stroke research · 2023Review
- Plasmon-activated water as a therapeutic strategy in Alzheimer's disease by altering gut microbiota.Aging · 2023Article
- The central role of peripheral inflammation in ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- The Bridge Between Ischemic Stroke and Gut Microbes: Short-Chain Fatty Acids.Cellular and molecular neurobiology · 2023Review
- Neuroprotective Strategies for Ischemic Stroke-Future Perspectives.International journal of molecular sciences · 2023Review
- Stroke and the risk of gastrointestinal disorders: A Mendelian randomization study.Frontiers in neurology · 2023Article
- The gastrointestinal-brain-microbiota axis: a promising therapeutic target for ischemic stroke.Frontiers in immunology · 2023Review
- Interventional strategies for ischemic stroke based on the modulation of the gut microbiota.Frontiers in neuroscience · 2023Review
- Microbiota-gut-brain axis impairment in the pathogenesis of stroke: implication as a potent therapeutic target.Bioscience of microbiota, food and health · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbiota research, in particular that of the gut, has recently gained much attention in medical research owing to technological advances in metagenomics and metabolomics. Despite this, much of the research direction has focused on long-term or chronic effects of microbiota manipulation on health and disease. In this addendum, we reflect on our recent publication that reported findings addressing a rather unconventional hypothesis. Bacterial pneumonia is highly prevalent and is one of the leading contributors to stroke morbidity and mortality worldwide. However, microbiological cultures of samples taken from stroke patient with a suspected case of pneumonia often return with a negative result. Therefore, we proposed that post-stroke infection may be due to the presence of anaerobic bacteria, possibly those originated from the host gut microbiota. Supporting this, we showed that stroke promotes intestinal barrier breakdown and robust microbiota changes, and the subsequent translocation of selective bacterial strain from the host gut microbiota to peripheral tissues (i.e. lung) induces post-stroke infections. Our findings were further supported by various elegant studies published in the past 12 months. Here, we discuss and provide an overview of our key findings, supporting studies, and the implications for future advances in stroke research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.