Evidence map›Paper›PMID 28640661›Full record

ArticleGlobal health action2017

Attrition from antiretroviral treatment services among pregnant and non-pregnant patients following adoption of Option B+ in Haiti.

Jean Wysler Domercant, Nancy Puttkammer, Paul Young, Krista Yuhas, Kesner François, Reynold Grand'Pierre, David Lowrance, Michelle Adler

Abstract readMulticenter Study
In one paragraph

Article in Global health action, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  9. Timely initiation of HIV antiretroviral therapy in Haiti 2004-2018: a retrospective cohort study.Revista panamericana de salud publica = Pan American journal of public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jean Wysler Domercanta Division of Global HIV & TB , Centers for Disease Control and Prevention , Port au Prince , Haiti.ORCID 0000-0001-7995-4111
Nancy Puttkammerb International Training and Education Center for Health , University of Washington , Seattle , WA , USA.
Paul Youngc Division of Global HIV/AIDS , Centers for Disease Control and Prevention , Atlanta , GA , USA.ORCID 0000-0002-5564-9486
Krista Yuhasd Center for AIDS Research , University of Washington , Seattle , WA , USA.
Kesner Françoise National AIDS Control Program , Ministry of Health of the Government of Haiti.
Reynold Grand'Pierref Department of Family Health , Ministry of Health of the Government of Haiti.
David Lowrancea Division of Global HIV & TB , Centers for Disease Control and Prevention , Port au Prince , Haiti.
Michelle Adlerg Division of Global HIV & TB , Centers for Disease Control and Prevention , Kampala , Uganda.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
CGH CDC HHS U2G GH001130NIAID NIH HHS P30 AI027757PEPFAR
6 · The paper itself

Abstract

backgroundAccess to antiretroviral therapy (ART) has expanded in Haiti because of the adoption of Option B+ and the revision of treatment guidelines. Retention in care and treatment varies greatly and few studies have examined retention rates, particularly among women enrolled in Option B+.

objectiveTo assess attrition among pregnant and non-pregnant patients initiating ART following adoption of Option B+ in Haiti.

methodsLongitudinal data of adult patients initiated on ART from October 2012 through August 2014 at 73 health facilities across Haiti were analyzed using a survival analysis framework to determine levels of attrition. The Kaplan-Meier method and Cox proportional hazards regression were used to examine risk factors associated with attrition.

resultsAmong 17,059 patients who initiated ART, 7627 (44.7%) were non-pregnant women, 5899 (34.6%) were men, and 3533 (20.7%) were Option B+ clients. Attrition from the ART program was 36.7% at 12 months (95% CI: 35.9-37.5%). Option B+ patients had the highest level of attrition at 50.4% at 12 months (95% CI: 48.6-52.3%). While early HIV disease stage at ART initiation was protective among non-pregnant women and men, it was a strong risk factor among Option B+ clients. In adjusted analyses, key protective factors were older age (p < 0.0001), living near the health facility (p = 0.04), having another known HIV-positive household member (p < 0.0001), having greater body mass index (BMI) (p < 0.0001), pre-ART counseling (p < 0.0001), and Cotrimoxazole prophylaxis during baseline (p < 0.01). Higher attrition was associated with rapidly starting ART after enrollment (p < 0.0001), anemia (p < 0.0001), and regimen tenofovir+lamivudine+nevirapine (TDF+3TC+NVP) (p < 0.001).

conclusionsART attrition in Haiti is high among adults, especially among Option B+ patients. Identifying newly initiated patients most at risk for attrition and providing appropriate interventions could help reduce ART attrition.

Indexed as

AdultAge FactorsAntiretroviral Therapy, Highly ActiveFemaleHaitiHIV InfectionsHIV SeropositivityHumansKaplan-Meier EstimateLongitudinal StudiesMaleMiddle AgedPatient Acceptance of Health CarePatient DropoutsPractice Guidelines as TopicPregnancyARTattritionHIVOption B+

Identifiers

PMID28640661
PMCPMC5496080

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.