ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2018
Sustained Posttransplantation Diabetes Is Associated With Long-Term Major Cardiovascular Events Following Liver Transplantation.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Early Postoperative Basal Insulin Therapy versus Standard of Care for the Prevention of Diabetes Mellitus after Kidney Transplantation: A Multicenter Randomized Trial.Journal of the American Society of Nephrology : JASN · 2021Trial
- Post-transplant diabetes mellitus requiring insulin identifies high-risk outcomes after solid organ transplantation.The Journal of clinical endocrinology and metabolism · 2026Article
- Major adverse cardiovascular events after liver transplantation: a population cohort analysis of English transplant centres.EClinicalMedicine · 2026Article
- Impact of Diverse Clinical Characteristics on Survival Benefit of Liver Transplantation.Journal of transplantation · 2026Article
- [Abdominal organ transplantation in multimorbid patients].Chirurgie (Heidelberg, Germany) · 2025Review
- Clinical characteristics of new-onset diabetes after liver transplantation and outcomes.Annals of gastroenterological surgery · 2024Article
- Review
- Use of machine learning models for the prognostication of liver transplantation: A systematic review.World journal of transplantation · 2024Article
- Metabolic Disorders in Liver Transplant Recipients: The State of the Art.Journal of clinical medicine · 2024Review
- Induction immunosuppression and post-transplant diabetes mellitus: a propensity-matched cohort study.Frontiers in endocrinology · 2023Article
- Diabetes and Metabolic Disorders: Their Impact on Cardiovascular Events in Liver Transplant Patients.Canadian journal of gastroenterology & hepatology · 2023Article
- The clinical implications of pre-liver transplant diabetes on post-liver transplant outcomes in patients with NASH: analysis of the UNOS database.Hepatology international · 2022Article
- Incidence, Risk Factors and Clinical Implications of Glucose Metabolic Changes after Heart Transplant.Biomedicines · 2022Article
- Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors Use for Atherogenic Dyslipidemia in Solid Organ Transplant Patients.Journal of clinical medicine · 2022Review
- 2020 Clinical Update in Liver Transplantation.Journal of cardiothoracic and vascular anesthesia · 2022Review
- Donor and recipient polygenic risk scores influence the risk of post-transplant diabetes.Nature medicine · 2022Article
- Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Is Intestinal Dysbiosis-Associated With Immunosuppressive Therapy a Key Factor in the Pathophysiology of Post-Transplant Diabetes Mellitus?Frontiers in endocrinology · 2022Article
- The Danish comorbidity in liver transplant recipients study (DACOLT): a non-interventional prospective observational cohort study.BMC gastroenterology · 2021Observational
- A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver Transplantation.Journal of clinical medicine · 2021Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Cardiovascular disease is a leading cause of death among liver transplant (LT) recipients. With a rising burden of posttransplantation metabolic disease, increases in cardiovascular-related morbidity and mortality may reduce life expectancy after LT. It is unknown if the risk of long-term major cardiovascular events (MCEs) differs among LT recipients with varying diabetic states. We performed a retrospective cohort study of LT recipients from 2003 through 2013 to compare the incidence of MCEs among patients (1) without diabetes, (2) with pretransplantation diabetes, (3) with de novo transient posttransplantation diabetes, and (4) with de novo sustained posttransplantation diabetes. We analyzed 994 eligible patients (39% without diabetes, 24% with pretransplantation diabetes, 16% with transient posttransplantation diabetes, and 20% with sustained posttransplantation diabetes). Median follow-up was 54.7 months. Overall, 12% of patients experienced a MCE. After adjustment for demographic and clinical variables, sustained posttransplantation diabetes was the only state associated with a significantly increased risk of MCEs (subdistribution hazard ratio 1.95, 95% confidence interval 1.20-3.18). Patients with sustained posttransplantation diabetes mellitus had a 13% and 27% cumulative incidence of MCEs at 5 and 10 years, respectively. While pretransplantation diabetes has traditionally been associated with cardiovascular disease, the long-term risk of MCEs is greatest in LT recipients with sustained posttransplantation diabetes mellitus.
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