Evidence map›Paper›PMID 28640253›Full record

ArticleCell death & disease2017

A role for TSPO in mitochondrial Ca

Jemma Gatliff, Daniel A East, Aarti Singh, Maria Soledad Alvarez, Michele Frison, Ivana Matic, Caterina Ferraina, Natalie Sampson, Federico Turkheimer, Michelangelo Campanella

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 100 citations in OpenAlex.

  1. Article
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  8. Review
  9. Article
  10. Article
  11. Increased [Biomolecules · 2025
    Article
  12. Role of Mitochondrial Dysfunction in Neuropathy.International journal of molecular sciences · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Jemma GatliffDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
Daniel A EastDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
Aarti SinghDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
Maria Soledad AlvarezDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
Michele FrisonDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
Ivana MaticDepartment of Biology, University of Rome 'TorVergata', 00133 Rome, Italy.
Caterina FerrainaRegina Elena-National Cancer Institute, 00144 Rome, Italy.
Natalie SampsonDivision of Experimental Urology, Medical University of Innsbruck, A6020 Innsbruck, Austria.
Federico TurkheimerDepartment of Neuroimaging, Institute of Psychiatry, King's College London, London, UK.
Michelangelo CampanellaDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK.
King's College London · GBRoyal Veterinary College · GBUniversity of London · GBUniversity of Rome Tor Vergata · ITInnsbruck Medical University · AT

Funding

Biotechnology and Biological Sciences Research Council BB/M010384/1Medical Research Council G0900891Medical Research Council G1100809Medical Research Council G1100809/2Medical Research Council MC_U120085814Medical Research Council MR/K022733/1
6 · The paper itself

Abstract

The 18 kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is adopted as a biomarker of brain conditions. TSPO inhibits the autophagic removal of mitochondria by limiting PARK2-mediated mitochondrial ubiquitination via a peri-organelle accumulation of reactive oxygen species (ROS). Here we describe that TSPO deregulates mitochondrial Ca

Indexed as

HomeostasisSignal TransductionStress, PhysiologicalAnimalsCalciumCyclic AMP-Dependent Protein KinasesEndoplasmic ReticulumGlutamic AcidHumansMiceMitochondriaMitochondrial MembranesModels, BiologicalNADPH OxidasesOxidation-ReductionPhosphorylationBzrp protein, mouseCalciumCyclic AMP-Dependent Protein KinasesGlutamic AcidNADPH OxidasesReactive Oxygen SpeciesReceptors, GABAVoltage-Dependent Anion Channels

Identifiers

PMID28640253
PMCPMC5520880
OpenAlexW2723023976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.