Evidence map›Paper›PMID 28640223›Full record

ArticleMetabolites2017

Non-Targeted Metabolomics Analysis of the Effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Heart, Muscle, Liver and Serum Metabolism In Vivo.

Brian C Jensen, Traci L Parry, Wei Huang, Amro Ilaiwy, James R Bain, Michael J Muehlbauer, Sara K O'Neal, Cam Patterson, Gary L Johnson, Monte S Willis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Genetic factors in the pathogenesis of cardio-oncology.Journal of translational medicine · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Metabolomic Perspectives in Antiblastic Cardiotoxicity and Cardioprotection.International journal of molecular sciences · 2019
    Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Brian C JensenDepartment of Medicine, Division of Cardiology, University of North Carolina, Chapel Hill, NC 27599, USA. brian_jensen@med.unc.edu.
Traci L ParryMcAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA. traci_parry@med.unc.edu.
Wei HuangMcAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA. weih@email.unc.edu.
Amro IlaiwySarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA. amroilaiwy@gmail.com.
James R BainSarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA. james.bain@duke.edu.
Michael J MuehlbauerSarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA. michael.muehlbauer@duke.edu.
Sara K O'NealSarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27701, USA. sara.o'neal@duke.edu.
Cam PattersonPresbyterian Hospital/Weill-Cornell Medical Center, New York, NY 10065, USA. cpatters@nyp.org.
Gary L JohnsonDepartment of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA. gary_johnson@med.unc.edu.
Monte S WillisMcAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA. monte_willis@med.unc.edu.
University of North Carolina at Chapel Hill · USDuke University · USCornell University · US

Funding

Myocyte specific regulation of metabolism and the response to biomechanical forceR01HL104129 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIS, MONTE S · 2010 to 2018
$3.3M
NHLBI NIH HHS R01 HL104129
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardiotoxicityerlotinibheartkinase inhibitorslivermetabolomicsmuscleserumsorafenib

Identifiers

PMID28640223
PMCPMC5618316
OpenAlexW2637834159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.