Observational studyMedicine2017
Targeted sequencing in FGF/FGFR genes and association analysis of variants for mandibular prognathism.
Observational study in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Craniofacial syndromes and class III phenotype: common genotype fingerprints? A scoping review and meta-analysis.Pediatric research · 2024Pooled it
- Genes and Pathways Associated with Skeletal Sagittal Malocclusions: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Genetic factors contributing to skeletal class III malocclusion: a systematic review and meta-analysis.Clinical oral investigations · 2021Pooled it
- Polymorphisms inJournal of Taibah University Medical Sciences · 2025Article
- Prevalence of Malocclusion Traits in Primary Dentition, 2010-2024: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- East Asian and Southern European craniofacial class III phenotype: two sides of the same coin?Clinical oral investigations · 2024Review
- Narrating the Genetic Landscape of Human Class I Occlusion: A Perspective-Infused Review.Journal of personalized medicine · 2023Article
- Towards Genetic Dissection of Skeletal Class III Malocclusion: A Review of Genetic Variations Underlying the Phenotype in Humans and Future Directions.Journal of clinical medicine · 2023Article
- COL1A1 and FGFR2 Single-Nucleotide Polymorphisms Found in Class II and Class III Skeletal Malocclusions in Javanese Population.European journal of dentistry · 2023Article
- The association of polymorphisms inSaudi journal of biological sciences · 2022Article
- Analysis ofGlobal medical genetics · 2021Article
- Targeted sequencing of NOTCH signaling pathway genes and association analysis of variants correlated with mandibular prognathism.Head & face medicine · 2021Article
- Genetic variants in tooth agenesis-related genes might be also involved in tooth size variations.Clinical oral investigations · 2021Article
- Genetics of Dentofacial and Orthodontic Abnormalities.Global medical genetics · 2020Review
- Masticatory muscle function affects the pathological conditions of dentofacial deformities.The Japanese dental science review · 2020Review
- Sub-clustering in skeletal class III malocclusion phenotypes via principal component analysis in a southern European population.Scientific reports · 2020Article
- Association between craniofacial morphological patterns and tooth agenesis-related genes.Progress in orthodontics · 2020Article
- Orthodontics and Genetics.Dental press journal of orthodontics · 2019Article
- Association between the FGFR1 rs13317 single nucleotide polymorphism and orbitale-nasion depth based on cephalometric images.Journal of human genetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify variants of the genes in fibroblast growth factors/fibroblast growth factor receptors (FGF/FGFR) signal pathway that predispose to mandibular prognathism (MP) in the general Chinese population systematically.Targeted sequencing of the FGF/FGFR genes was conducted in 176 MP individuals and 155 class I malocclusion controls. The associations of common and rare variants with MP as a categorical phenotype and also continuous malocclusion phenotypes generated by principal component (PC) analysis were analyzed.One common variant, rs372127537, located in the 3'-untranslated region of FGF7 gene, was significantly related to PC1 (P = 4.22 × 10), which explained 23.23% of the overall phenotypic variation observed and corresponded to vertical discrepancies ranging from short anterior face height to long anterior face height, after Bonferroni correction. Also, 15 other variants were associated with PC1-4, although not significant after multiple corrections (P < .05). We also identified 3 variants: rs13317 in FGFR1, rs149242678 in FGF20, and rs79176051 FGF12 associated with MP (P < .05). With respect to rare variant analysis, variants within the FGF12 gene showed significant association with MP (P = .001).Association between FGF/FGFR signaling pathway and MP has been identified. We found a previously unreported SNP in FGF7 significantly related to increased facial height. Also, rare variants within the FGF12 were associated with MP. Our results provide new clues for genetic mechanisms of MP and shed light on strategies for evaluating rare variants that underlie complex traits. Future studies with larger sample sizes and more comprehensive genome coverage, and also in other population are required to replicate these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.