ArticleJournal of the American Chemical Society2017
Programmable Assembly of Peptide Amphiphile via Noncovalent-to-Covalent Bond Conversion.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Leveraging Molecular Weight Dispersity for Scalable, Precise Synthesis of Nanocylinders Via Quasi-Polymerization-Induced Self-Assembly.Angewandte Chemie (International ed. in English) · 2026Article
- Nonionic peptide amphiphiles and their supramolecular co-assemblies tune charge density and bioactivity.Journal of materials chemistry. B · 2026Article
- Programming Hydrogel Mechanics via Sequence-Controlled Polymerization Using Peptide Self-Assembly.Journal of the American Chemical Society · 2026Article
- Harnessing Amino Acid Modularity for Programmable Function in Covalent Peptide Assemblies.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Peptide-Based Biomaterials for Combatting Infections and Improving Drug Delivery.Pharmaceutics · 2024Review
- Water-Assisted Programmable Assembly of Flexible and Self-Standing Janus Membranes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Lipopeptides as tools in catalysis, supramolecular, materials and medicinal chemistry.Nature reviews. Chemistry · 2023Review
- Peptide Amphiphile Supramolecular Nanofibers Designed to Target Abdominal Aortic Aneurysms.ACS nano · 2022Article
- Spatiotemporal dynamics of supramolecular polymers byChemical science · 2022Article
- Selective covalent capture of collagen triple helices with a minimal protecting group strategy.Chemical science · 2022Article
- Bioinspired photo-crosslinkable self-assembling peptides with pH-switchable "on-off" luminescence.Nanoscale advances · 2022Article
- Intravenous Delivery of Lung-Targeted Nanofibers for Pulmonary Hypertension in Mice.Advanced healthcare materials · 2021Article
- Controlling Structure with Injectable Biomaterials to Better Mimic Tissue Heterogeneity and Anisotropy.Advanced healthcare materials · 2021Review
- Current Progress in Cross-Linked Peptide Self-Assemblies.International journal of molecular sciences · 2020Review
- Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos.Frontiers in bioengineering and biotechnology · 2020Review
- Designing stable, hierarchical peptide fibers from block co-polypeptide sequences.Chemical science · 2019Article
- Supramolecular Self-Assembly To Control Structural and Biological Properties of Multicomponent Hydrogels.Chemistry of materials : a publication of the American Chemical Society · 2019Article
- Peptide Tectonics: Encoded Structural Complementarity Dictates Programmable Self-Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Review
- MMP-2-Controlled Transforming Micelles for Heterogeneic Targeting and Programmable Cancer Therapy.Theranostics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Controlling the number of monomers in a supramolecular polymer has been a great challenge in programmable self-assembly of organic molecules. One approach has been to make use of frustrated growth of the supramolecular assembly by tuning the balance of attractive and repulsive intermolecular forces. We report here on the use of covalent bond formation among monomers, compensating for intermolecular electrostatic repulsion, as a mechanism to control the length of a supramolecular nanofiber formed by self-assembly of peptide amphiphiles. Circular dichroism spectroscopy in combination with dynamic light scattering, size-exclusion chromatography, and transmittance electron microscope analyses revealed that hydrogen bonds between peptides were reinforced by covalent bond formation, enabling the fiber elongation. To examine these materials for their potential biomedical applications, cytotoxicity of nanofibers against C2C12 premyoblast cells was tested. We demonstrated that cell viability increased with an increase in fiber length, presumably because of the suppressed disruption of cell membranes by the fiber end-caps.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.